The transcriptional landscape of age in human peripheral blood
MetadataShow full item record
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the ‘transcriptomic age’ of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.
Showing items related by title, author, creator and subject.
Yong, H.; Melton, P.; Johnson, M.; Freed, K.; Kalionis, B.; Murthi, P.; Brennecke, S.; Keogh, R.; Moses, Eric (2015)Background: Preeclampsia (PE) is a serious hypertensive pregnancy disorder with a significant genetic component. Numerous genetic studies, including our own, have yielded many susceptibility genes from distinct functional ...
Kochunov, P.; Charlesworth, J.; Winkler, A.; Hong, L.; Nichols, T.; Curran, J.; Sprooten, E.; Jahanshad, N.; Thompson, P.; Johnson, M.; Kent, J.; Landman, B.; Mitchell, B.; Cole, S.; Dyer, T.; Moses, Eric; Goring, H.; Almasy, L.; Duggirala, R.; Olvera, R.; Glahn, D.; Blangero, J. (2013)Introduction: We performed a whole-transcriptome correlation analysis, followed by the pathway enrichment and testing of innate immune response pathway analyses to evaluate the hypothesis that transcriptional activity can ...
Gene networks in skeletal muscle following endurance exercise are coexpressed in blood neutrophils and linked with blood inflammation markersBroadbent, J.; Sampson, D.; Sabapathy, S.; Haseler, Luke; Wagner, K.; Bulmer, A.; Peake, J.; Neubauer, O. (2017)Copyright © 2017 the American Physiological Society. It remains incompletely understood whether there is an association between the transcriptome profiles of skeletal muscle and blood leukocytes in response to exercise ...