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dc.contributor.authorTran, B.
dc.contributor.authorWhiteman, D.
dc.contributor.authorWebb, P.
dc.contributor.authorFritschi, Lin
dc.contributor.authorFawcett, J.
dc.contributor.authorRisch, H.
dc.contributor.authorLucas, R.
dc.contributor.authorPandeya, N.
dc.contributor.authorSchulte, A.
dc.contributor.authorNeale, R.
dc.identifier.citationTran, B. and Whiteman, D. and Webb, P. and Fritschi, L. and Fawcett, J. and Risch, H. and Lucas, R. et al. 2013. Association Between Ultraviolet Radiation, Skin Sun Sensitivity and Risk of Pancreatic Cancer. Cancer Epidemiology: the international journal of cancer epidemiology, detection and prevention. 37: pp. 886-892.

Background: Ecological studies showing an inverse association between pancreatic cancer incidence and mortality and levels of ultraviolet radiation (UVR), suggest that higher levels of sun exposure may reduce risks of pancreatic cancer but there has been only one individual-level study that examined this issue. We aimed to examine the association between pancreatic cancer and markers of exposure to solar UVR, namely skin type, treatment of skin lesions, ambient UVR and time outdoors on work days. Methods: We used data from an Australian case-control study. Location at birth, residential location during adulthood, outdoors work, history of skin lesion treatment and sensitivity of the skin to the sun were obtained by questionnaire. We limited the analyses to Caucasians who answered the questionnaire about UVR (controls = 589/711 recruited; cases = 496/705 recruited). We used NASA’s Total Ozone Mapping Spectrometer to estimate ambient UVR. Results: Being born in or living in areas of higher ambient UVR (compared to lower ambient UVR) was associated with about 30–40% lower risk of pancreatic cancer. People with fair skin colour had 47% lower risk of pancreatic cancer than those with dark skin colour (95% CI 0.37–0.75). There was some suggestion of increased risk with increased average number of hours spent outside at work. Conclusions: This study suggests that people with light skin colour or those born or living in areas of high ambient UVR have lower risk of pancreatic cancer. Our analysis supports an association between UVR and pancreatic cancer, possibly mediated through production of vitamin D.

dc.publisherElsevier Inc.
dc.subjectHistory of skin cancer
dc.subjectSkin colour
dc.subjectSkin type
dc.subjectUltraviolet radiation
dc.subjectPancreatic cancer
dc.titleAssociation Between Ultraviolet Radiation, Skin Sun Sensitivity and Risk of Pancreatic Cancer
dc.typeJournal Article
dcterms.source.titleCancer Epidemiology: the international journal of cancer epidemiology, detection and prevention
curtin.accessStatusFulltext not available

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