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    Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer

    Access Status
    Fulltext not available
    Authors
    Neale, R.
    Clark, P.
    Fawcett, J.
    Fritschi, Lin
    Nagler, B.
    Risch, H.
    Walters, R.
    Crawford, W.
    Webb, P.
    Whiteman, D.
    Buchanan, D.
    Date
    2014
    Type
    Journal Article
    
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    Citation
    Neale, R. and Clark, P. and Fawcett, J. and Fritschi, L. and Nagler, B. and Risch, H. and Walters, R. et al. 2014. Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer. Cancer Epidemiology: The International Journal of Cancer Epidemiology, Detection and Prevention. 38 (5): pp. 576-582.
    Source Title
    Cancer Epidemiology: the international journal of cancer epidemiology, detection and prevention
    DOI
    10.1016/j.canep.2014.08.006
    ISSN
    1877-7821
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/42957
    Collection
    • Curtin Research Publications
    Abstract

    Pancreatic cancer is a leading cause of cancer-related deaths worldwide. Methylation of DNA may influence risk or be a marker of early disease. The aim of this study was to measure the association between methylation of three DNA repetitive elements in white blood cell (WBC) DNA and pancreatic cancer. DNA from WBCs of pancreatic cancer cases (n = 559) and healthy unrelated controls (n = 603) were tested for methylation of the LINE-1, Alu and Sat2 DNA repetitive elements using MethyLight quantitative PCR assays. Odds ratios (ORs) and 95% confidence intervals (95%CI) between both continuous measures of percent of methylated sample compared to a reference (PMR) or quintiles of PMR and pancreatic cancer, adjusted for age, sex, smoking, BMI, alcohol and higher education, were estimated. The PMR for each of the three markers was higher in cases than in controls, although only LINE-1 was significantly associated with pancreatic cancer (OR per log unit = 1.37, 95%CI = 1.16–1.63). The marker methylation score for all three markers combined was significantly associated with pancreatic cancer (p-trend = 0.0006). There were no associations between measures of PMR and either presence of metastases, or timing of blood collection in relation to diagnosis, surgery, chemotherapy or death (all p > 0.1). We observed an association between methylation of LINE-1 in WBC DNA and risk of pancreatic cancer. Further studies are needed to confirm this association.

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