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    Haemodynamic analysis of the effect of different types of plaques in the left coronary artery

    192087_192087.pdf (1.029Mb)
    Access Status
    Open access
    Authors
    Thanapong, Chaichana
    Sun, Zhonghua
    Jewkes, James
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Thanapong, Chaichana and Sun, Zhonghua and Jewkes, James. 2013. Haemodynamic analysis of the effect of different types of plaques in the left coronary artery. Computerized Medical Imaging and Graphics. 37 (3): pp. 197-206.
    Source Title
    Computerized Medical Imaging and Graphics
    DOI
    10.1016/j.compmedimag.2013.02.001
    ISSN
    0895-6111
    Remarks

    This is the author’s version of a work that was accepted for publication in the journal Computerized Medical Imaging and Graphics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in the Journal Computerized Medical Imaging and Graphics, Vol.37, No.3 (2013). DOI: 10.1016/j.compmedimag.2013.02.001.

    URI
    http://hdl.handle.net/20.500.11937/15241
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: Coronary plaque has been shown to directly affect the blood parameters, however, haemodynamic variations based on the plaque configuration has not been studied. In this study we investigate the haemodynamic effects of various types of plaques in the left coronary bifurcation. Methods: Eight types of plaque configurations were simulated and located in various positions in the left main stem, the left anterior descending and left circumflex to produce a >50% narrowing of the coronary lumen. We analyse and characterise haemodynamic effects caused by each type of plaque. Computational fluid dynamics was performed to simulate realistic physiological conditions that reveal the in vivo cardiac haemodynamics. Velocity, wall shear stress (WSS) and pressure gradient (PSG) in the left coronary artery were calculated and compared in all plaque configurations during cardiac cycles. Results: Our results showed that the highest velocity and PSG were found in the type of plaque configuration which involved all of the three left coronary branches. Plaques located in the left circumflex branch resulted in highly significant changes of the velocity, WSS and PSG (p < 0.001) when compared to the other types of plaque configurations. Conclusion: Our analysis provides an insight into the distribution of plaque at the left bifurcation, and corresponding haemodynamic effects, thus, improving our understanding of atherosclerosis.

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