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    Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency

    Access Status
    Fulltext not available
    Authors
    Lim, A.
    Allison, C.
    Price, Patricia
    Waterer, G.
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Citation
    Lim, A. and Allison, C. and Price, P. and Waterer, G. 2010. Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency. Clinical Immunology. 137 (2): pp. 296-302.
    Source Title
    Clinical Immunology
    DOI
    10.1016/j.clim.2010.07.011
    ISSN
    1521-6616
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/15281
    Collection
    • Curtin Research Publications
    Abstract

    It remains unclear why some individuals and not others are susceptible to non-tuberculous mycobacterial lung disease (NTMLD). To determine whether NTMLD is associated with defects or biases in Th1/Th2/Th17 immunity, blood leukocytes from NTM patients with nodular bronchiectasis, their adult offspring, and healthy population controls were stimulated with staphylococcal enterotoxin B (SEB), tuberculin and sensitin to measure cytokine production. In response to SEB, NTM patients exhibited higher frequencies of IFN?-producing CD4 + T cells than population controls (P<0.001). In supernatant, levels of IL-17 were lower in patients than adult offspring. Sensitin elicited higher IFN? responses from patients than controls (P<0.05). Patients also produced more IL-10 in supernatant than controls after culture with tuberculin (P<0.01) or sensitin (P<0.05), but IL-10-producing CD4 + T cells were undetectable. NTMLD is not associated with deficient IFN? production, but may be associated with reduced Th17 immunity and/or a predisposition towards IL-10 production from non-CD4 + T cells. © 2010 Elsevier Inc.

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