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dc.contributor.authorLim, A.
dc.contributor.authorAllison, C.
dc.contributor.authorPrice, Patricia
dc.contributor.authorWaterer, G.
dc.date.accessioned2017-01-30T11:49:01Z
dc.date.available2017-01-30T11:49:01Z
dc.date.created2016-09-12T08:36:57Z
dc.date.issued2010
dc.identifier.citationLim, A. and Allison, C. and Price, P. and Waterer, G. 2010. Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency. Clinical Immunology. 137 (2): pp. 296-302.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/15281
dc.identifier.doi10.1016/j.clim.2010.07.011
dc.description.abstract

It remains unclear why some individuals and not others are susceptible to non-tuberculous mycobacterial lung disease (NTMLD). To determine whether NTMLD is associated with defects or biases in Th1/Th2/Th17 immunity, blood leukocytes from NTM patients with nodular bronchiectasis, their adult offspring, and healthy population controls were stimulated with staphylococcal enterotoxin B (SEB), tuberculin and sensitin to measure cytokine production. In response to SEB, NTM patients exhibited higher frequencies of IFN?-producing CD4 + T cells than population controls (P<0.001). In supernatant, levels of IL-17 were lower in patients than adult offspring. Sensitin elicited higher IFN? responses from patients than controls (P<0.05). Patients also produced more IL-10 in supernatant than controls after culture with tuberculin (P<0.01) or sensitin (P<0.05), but IL-10-producing CD4 + T cells were undetectable. NTMLD is not associated with deficient IFN? production, but may be associated with reduced Th17 immunity and/or a predisposition towards IL-10 production from non-CD4 + T cells. © 2010 Elsevier Inc.

dc.publisherAcademic Press
dc.titleSusceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency
dc.typeJournal Article
dcterms.source.volume137
dcterms.source.number2
dcterms.source.startPage296
dcterms.source.endPage302
dcterms.source.issn1521-6616
dcterms.source.titleClinical Immunology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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