Curtin University Homepage
  • Library
  • Help
    • Log in

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: A systematic review and meta-analysis

    Access Status
    Fulltext not available
    Authors
    Huxley, Rachel
    Peters, S.
    Mishra, G.
    Woodward, M.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Abstract

    © 2015 Elsevier Ltd. Background: Studies have suggested sex differences in the mortality rate associated with type 1 diabetes. We did a meta-analysis to provide reliable estimates of any sex differences in the effect of type 1 diabetes on risk of all-cause mortality and cause-specific outcomes. Methods: We systematically searched PubMed for studies published between Jan 1, 1966, and Nov 26, 2014. Selected studies reported sex-specific estimates of the standardised mortality ratio (SMR) or hazard ratios associated with type 1 diabetes, either for all-cause mortality or cause-specific outcomes. We used random effects meta-analyses with inverse variance weighting to obtain sex-specific SMRs and their pooled ratio (women to men) for all-cause mortality, for mortality from cardiovascular disease, renal disease, cancer, the combined outcome of accident and suicide, and from incident coronary heart disease and stroke associated with type 1 diabetes. Findings: Data from 26 studies including 214 114 individuals and 15 273 events were included. The pooled women-to-men ratio of the SMR for all-cause mortality was 1·37 (95% CI 1·21-1·56), for incident stroke 1·37 (1·03-1·81), for fatal renal disease 1·44 (1·02-2·05), and for fatal cardiovascular diseases 1·86 (1·62-2·15). For incident coronary heart disease the sex difference was more extreme; the pooled women-to-men ratio of the SMR was 2·54 (95% CI 1·80-3·60). No evidence suggested a sex difference for mortality associated with type 1 diabetes from cancer, or accident and suicide. Interpretation: Women with type 1 diabetes have a roughly 40% greater excess risk of all-cause mortality, and twice the excess risk of fatal and nonfatal vascular events, compared with men with type 1 diabetes. Funding: None.

    Citation
    Huxley, R. and Peters, S. and Mishra, G. and Woodward, M. 2015. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: A systematic review and meta-analysis. The Lancet Diabetes and Endocrinology. 3 (3): pp. 198-206.
    Source Title
    The Lancet Diabetes and Endocrinology
    DOI
    10.1016/S2213-8587(14)70248-7
    ISSN
    2213-8587
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/15312
    Collection
    • Curtin Research Publications

    Related items

    Showing items related by title, author, creator and subject.

    • Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980?793 adults from 68 prospective studies
      Gnatiuc, L.; Herrington, W.; Halsey, J.; Tuomilehto, J.; Fang, X.; Kim, H.; De Bacquer, D.; Dobson, A.; Criqui, M.; Jacobs, D.; Leon, D.; Peters, S.; Ueshima, H.; Sherliker, P.; Peto, R.; Collins, R.; Huxley, Rachel; Emberson, J.; Woodward, M.; Lewington, S.; Aoki, N.; Arima, H.; Arnesen, E.; Aromaa, A.; Assmann, G.; Bachman, D.; Baigent, C.; Bartholomew, H.; Benetos, A.; Bengtsson, C.; Bennett, D.; Björkelund, C.; Blackburn, H.; Bonaa, K.; Boyle, E.; Broadhurst, R.; Carstensen, J.; Chambless, L.; Chen, Z.; Chew, S.; Clarke, R.; Cox, C.; Curb, J.; D'Agostino, R.; Date, C.; Davey Smith, G.; De Backer, G.; Dhaliwal, S.; Duan, X.; Ducimetiere, P.; Duffy, S.; Eliassen, H.; Elwood, P.; Empana, J.; Garcia-Palmieri, M.; Gazes, P.; Giles, G.; Gillis, C.; Goldbourt, U.; Gu, D.; Guasch-Ferre, M.; Guize, L.; Haheim, L.; Hart, C.; Hashimoto, S.; Hashimoto, T.; Heng, D.; Hjermann, I.; Ho, S.; Hobbs, M.; Hole, D.; Holme, I.; Horibe, H.; Hozawa, A.; Hu, F.; Hughes, K.; Iida, M.; Imai, K.; Imai, Y.; Iso, H.; Jackson, R.; Jamrozik, K.; Jee, S.; Jensen, G.; Jiang, C.; Johansen, N.; Jorgensen, T.; Jousilahti, P.; Kagaya, M.; Keil, J.; Keller, J.; Kim, I.; Kita, Y.; Kitamura, A.; Kiyohara, Y.; Knekt, P.; Knuiman, M.; Kornitzer, M.; Kromhout, D.; Kronmal, R. (2018)
      © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Several studies have shown that diabetes confers a higher relative risk of vascular mortality among ...
    • The harms of smoking and benefits of smoking cessation in women compared with men with type 2 diabetes: an observational analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial
      Blomster, J.; Woodward, M.; Zoungas, S.; Hillis, G.; Harrap, S.; Neal, B.; Poulter, N.; Mancia, G.; Chalmers, J.; Huxley, Rachel (2016)
      OBJECTIVES: In general populations, the adverse effects of smoking on coronary risk have been demonstrated to be greater in women than in men; whether this is true for individuals with diabetes is unclear. DESIGN: Cohort ...
    • Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
      Miller, Ted (2015)
      SummaryBackground Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden ...

    Browse

    Communities & CollectionsIssue DateAuthorsTitlesSubjectsDocument TypesThis CollectionIssue DateAuthorsTitlesSubjectsDocument Types

    My Account

    Log in

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Connect with Curtin

    • 
    • 
    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158