Electrospun PLA/PCL fibers with tubular nanoclay: morphological and structural analysis
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Biodegradable polymers are good candidates for a wide range of applications in tissue engineering and drug delivery because of their biocompatibility, their degradation, mechanical properties, and offer a sustained release of encapsulated drugs. The electrospun polymer nanofibrous materials can be used as carriers for hydrophobic and hydrophilic drugs. This research work focused on poly(lactic acid) (PLA) and blends of PLA with poly (ε-caprolactone) (PCL) that are reinforced with different concentrations of halloysite nanotubes (HNTs) and various cosolvents for electrospinning including chloroform : acetone, chloroform : methanol, and dichloromethane (DCM) : N,N, dimethylformamide (DFM). The fibers produced from the DCM : DMF system without HNTs were more uniform resulting in smaller fiber diameters as compared to the chloroform: methanol system due to the increased solution conductivity. The addition of HNT nanoparticles produced electrospun fibers with large diameters because the viscosity of the solution increased. Cosolvent was important in determining fiber diameters because it strongly influenced the solution viscosity and conductivity. HNTs had relatively small impact on the growth of a crystalline morphology in PCL–HNT composites. The solvent mixture of chloroform : methanol was better for PLA-based systems since PLA was found to have slightly higher crystallinity and larger enthalpy value indicating the improved structural orderness in the PLA polymer matrix
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Haroosh, Hazim; Chaudhary, Deeptangshu; Dong, Yu (2011)This research work focused on studying two different concentrations of poly (ε-caprolactone) (PCL) and blends of PCL with Poly (lactic acid) (PLA) at five blending rations and that are dissolved in different co-solvents ...
Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug deliveryHaroosh, Hazim Jasim Mohammed; Dong, Yu (2015)Differing from general melt polymer blending, a sophisticated electrospinning technique to produce continuous polylactic acid (PLA) and poly(ε-caprolactone) (PCL) hybrid fibers was employed to develop favorable fibrous ...
Electrospun poly(lactic acid) (PLA): poly(ε-caprolactone) (PCL)/halloysite nanotube (HNT) composite fibers: Synthesis and characterizationHaroosh, Hazim; Dong, Yu (2015)The incorporation of nanoparticles into polymer nanocomposites via electrospinning offers an effective approach to tailor composite properties and fabricate nonwoven fibrous structures. This chapter describes a general ...