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    Are elastic liposomes better for skin delivery of therapeutic molecules?

    Jahan F 2011.pdf (2.411Mb)
    Access Status
    Open access
    Authors
    Jahan, Fatima Naushin
    Date
    2011
    Supervisor
    Dr Yan Chen
    Assoc. Prof. Heather Benson
    Type
    Thesis
    Award
    MPharm
    
    Metadata
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    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/1623
    Collection
    • Curtin Theses
    Abstract

    The objectives of the present study were to design and evaluate elastic liposomes in comparison to simple drug solution and conventional liposomes, and in delivering a model NSAID, Ibuprofen (IBU) across human epidermis after topical application. The scope of the project included formulation development, characterization, and optimization based on their physical characteristics and determination of IBU penetration when incorporated in conventional and elastic liposomes through human epidermis after topical application, and finally to establish the relationship between the formulation variables and skin penetration of IBU loaded liposomes.

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