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    Barriers to liposomal gene delivery: From application site to the target

    Access Status
    Fulltext not available
    Authors
    Saffari, M.
    Moghimi, H.
    Dass, Crispin
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Saffari, M. and Moghimi, H. and Dass, C. 2016. Barriers to liposomal gene delivery: From application site to the target. Iranian Journal of Pharmaceutical Research. 15: pp. 3-17.
    Source Title
    Iranian Journal of Pharmaceutical Research
    Additional URLs
    http://ijpr.sbmu.ac.ir/article_1859.html
    ISSN
    1735-0328
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/41823
    Collection
    • Curtin Research Publications
    Abstract

    Gene therapy is a therapeutic approach to deliver genetic material into cells to alter their function in entire organism. One promising form of gene delivery system (DDS) is liposomes. The success of liposome-mediated gene delivery is a multifactorial issue and well-designed liposomal systems might lead to optimized gene transfection particularly in vivo. Liposomal gene delivery systems face different barriers from their site of application to their target, which is inside the cells. These barriers include presystemic obstacles (epithelial barriers), systemic barriers in blood circulation and cellular barriers. Epithelial barriers differ depending on the route of administration. Systemic barriers include enzymatic degradation, binding and opsonisation. Both of these barriers can act as limiting hurdles that genetic material and their vector should overcome before reaching the cells. Finally liposomes should overcome cellular barriers that include cell entrance, endosomal escape and nuclear uptake. These barriers and their impact on liposomal gene delivery will be discussed in this review.

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