Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release
MetadataShow full item record
Electrospun nanofibrous hybrid composite structures were prepared by blending poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) solutions and then mixed with three different amounts (0.01, 0.1 and 1% wt/v) of iron oxide (Fe3O4) magnetic nanoparticles (MPs),carrying a therapeutic compound tetracycline hydrochloride (TCH) with the potential use for medical applications. The material system was investigated to understand how constituents of hybrid composites influenced the surface morphology to control drug release. It has been found that fibre properties are strongly related to the viscosity and electrical conductivity of prepared solutions. The addition of MPs increased moderately the solution viscosities and produced quite uniform nanofibres. The fibre diameter decreased with increasing MP concentration due to significantly enhanced solution conductivity in presence of MPs. Crystallinity and Tg of PCL and Tc of PLA decreased when MPs were mixed with the polymer blend. TCH loading appears to result in decreasing nanofibre diameters and cause to decrease Tg and Tm values of PCL. TCH release was accelerated by adding MPs to the blended polymers.
Showing items related by title, author, creator and subject.
Haroosh, Hazim Jasim Mohammed; Dong, Yu (2014)Biopolymers show the excellent biodegradability and efficient release sustainability for encapsulated drugs. In particular, electrospun polymer or composite fibre mats provide greater benefits owing to their competitive ...
Sudarisman (2009)The flexural behaviour of three different hybrid fibre-reinforced polymer (FRP) matrix composites, i.e. S2-glass/E-glass/epoxy, TR50S carbon/IM7 carbon/epoxy, and E-glass/TR50S carbon/epoxy hybrid FRP composites, has been ...
Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery systemMeng, Z.; Xu, X.; Zheng, W.; Zhou, H.; Li, L.; Zheng, Y.; Lou, Xia (2011)Drug (Fenbufen, FBF)-loaded poly(D,L-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking ...