Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Evaluation of Electrospun Nanofibrous Structures for Drug Release Application

    203499_129641_Hazim___Yu_Chemeca_2014_Final_Paper.pdf (646.1Kb)
    Access Status
    Open access
    Authors
    Haroosh, Hazim Jasim Mohammed
    Dong, Yu
    Date
    2014
    Type
    Conference Paper
    
    Metadata
    Show full item record
    Citation
    Haroosh, H.J.M. and Dong, Y. 2014. Evaluation of Electrospun Nanofibrous Structures for Drug Release Application, in Pareek, V. and Leong, Y.-K. and Mullett, M. (ed), CHEMECA , Sep 28-Oct 01 2014. Perth, Australia: The Institution of Chemical Engineers (IChemE).
    Source Title
    Conference Proceedings of CHEMECA 2014
    Source Conference
    CHEMECA 2014
    Additional URLs
    http://www.icheme.org/chemeca2014/program/papers.aspx
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/27438
    Collection
    • Curtin Research Publications
    Abstract

    Biopolymers show the excellent biodegradability and efficient release sustainability for encapsulated drugs. In particular, electrospun polymer or composite fibre mats provide greater benefits owing to their competitive release properties and large specific surface area. This research work focused on electrospun nanofibres derived from poly(e-caprolactone) (PCL), poly(lactic acid) (PLA) and PCL/ magnetic nanoparticles (MPs) solutions by carrying a therapeutic compound tetracycline hydrochloride (TCH) with the potential use for medical applications. The material systems were examined to evaluate how composite constituents affected the surface morphology with the aim of drug release control. It has been found that the fibre diameter decreased considerably with the addition of TCH drug. The average fibre diameter was also reduced with additional MPs due to enhanced solution conductivity. Furthermore, Fourier transform infrared spectroscopy (FTIR) proved the successful encapsulation of TCH drug. Over short-term periods, the TCH release from PCL nanofibres was higher than PCL/ MPs and PLA nanofibres; whereas, on a long-term run, TCH release from PCL became slower owing to its high degree of crystallinity. The TCH release kinetics of PCL/ TCH nanofibres were better estimated by Zeng model when compared with PLA/TCH counterparts.

    Related items

    Showing items related by title, author, creator and subject.

    • Morphological Structures and Drug Release Effect of Multiple Electrospun Nanofibre Membrane Systems Based on PLA, PCL and PCL/Magnetic Nanoparticle Composites
      Haroosh, Hazim; Dong, Roger ; Jasim, Shaimaa; Ramakrishna, Seeram (2022)
      Biopolymers are good carrier materials in relation to efficient release sustainability for encapsulated drugs. In particular, electrospun polymer/composite fibre membranes can offer greater benefits owing to their competitive ...
    • Improvement of Drug Release and Compatibility between Hydrophilic Drugs and Hydrophobic Nanofibrous Composites
      Haroosh, Hazim; Dong, Roger ; Jasim, Shaimaa; Ramakrishna, Seeram (2021)
      Electrospinning is a flexible polymer processing method to produce nanofibres, which can be applied in the biomedical field. The current study aims to develop new electrospun hybrid nanocomposite systems to benefit the ...
    • Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system
      Meng, Z.; Xu, X.; Zheng, W.; Zhou, H.; Li, L.; Zheng, Y.; Lou, Xia (2011)
      Drug (Fenbufen, FBF)-loaded poly(D,L-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.