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    Interleukin-10 (IL-10) polymorphisms are associated with IL-10: Production and clinical malaria in young children

    Access Status
    Open access via publisher
    Authors
    Zhang, Guicheng
    Manaca, M.
    McNamara-Smith, M.
    Mayor, A.
    Nhabomba, A.
    Berthoud, T.
    Khoo, S.
    Wiertsema, S.
    Aguilar, R.
    Barbosa, A.
    Quintó, L.
    Candelaria, P.
    Schultz, E.
    Hayden, C.
    Goldblatt, J.
    Guinovart, C.
    Alonso, P.
    LeSouëf, P.
    Dobaño, C.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Zhang, G. and Manaca, M. and McNamara-Smith, M. and Mayor, A. and Nhabomba, A. and Berthoud, T. and Khoo, S. et al. 2012. Interleukin-10 (IL-10) polymorphisms are associated with IL-10: Production and clinical malaria in young children. Infection and Immunity. 80 (7): pp. 2316-2322.
    Source Title
    Infection and Immunity
    DOI
    10.1128/IAI.00261-12
    ISSN
    0019-9567
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/16268
    Collection
    • Curtin Research Publications
    Abstract

    The role of interleukin-10 (IL-10) in malaria remains poorly characterized. The aims of this study were to investigate (i) whether genetic variants of the IL-10 gene influence IL-10 production and (ii) whether IL-10 production as well as the genotypes and haplotypes of the IL-10 gene in young children and their mothers are associated with the incidence of clinical malaria in young children. We genotyped three IL-10 single nucleotide polymorphisms in 240 children and their mothers from a longitudinal prospective cohort and assessed the IL-10 production by maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs). Clinical episodes of Plasmodium falciparum malaria in the children were documented until the second year of life. The polymorphism IL-10 A-1082G (GCC haplotype of three SNPs in IL-10) in children was associated with IL-10 production levels by CBMC cultured with P. falciparum-infected erythrocytes (P=0.043), with the G allele linked to low IL-10 production capacity. The G allele in children was also significantly associated with a decreased risk for clinical malaria infection in their second year of life (P=0.016). Furthermore, IL-10 levels measured in maternal PBMCs cultured with infected erythrocytes were associated with increased risk of malaria infection in young children (P<0.001). In conclusion, IL-10 polymorphisms and IL-10 production capacity were associated with clinical malaria infections in young children. High IL-10 production capacity inherited from parents may diminish immunological protection against P. falciparum infection, thereby being a risk for increased malaria morbidity. © 2012, American Society for Microbiology.

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