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    Plasma Advanced Oxidative Protein Products are Associated with Anti-oxidative Stress Pathway Genes and Malaria in a Longitudinal Cohort.

    199292_117589_Plasma_advanced_oxidative_protein_products.pdf (433.8Kb)
    Access Status
    Open access
    Authors
    Zhang, Guicheng
    Skorokhod, O.
    Khoo, S.
    Aguilar, R.
    Wiertsema, S.
    Nhabomba, A.
    Marrocco, T.
    McNamara-Smith, M.
    Manaca, M.
    Barbosa, A.
    Quintó, L.
    Hayden, C.
    Goldblatt, J.
    Guinovart, C.
    Alonso, P.
    Dobaño, C.
    Schwarzer, E.
    LeSouëf, P.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Zhang, G. and Skorokhod, O. and Khoo, S. and Aguilar, R. and Wiertsema, S. and Nhabomba, A. and Marrocco, T. et al. 2014. Plasma Advanced Oxidative Protein Products are Associated with Anti-oxidative Stress Pathway Genes and Malaria in a Longitudinal Cohort. Malaria Journal. 13: Article ID 134.
    Source Title
    Malaria Journal
    DOI
    10.1186/1475-2875-13-134
    ISSN
    1475-2875
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/34208
    Collection
    • Curtin Research Publications
    Abstract

    BACKGROUND: Advanced oxidation protein products (AOPP) are newly identified efficient oxidative stress biomarkers. In a longitudinal birth cohort the effects were investigated of genetic polymorphisms in five oxidative pathway genes on AOPP levels. METHODS: This study is part of a three-arm randomized, double-blind, placebo-controlled trial. Three hundred and twelve children were included in the present study with AOPP levels measured at 2.5, 5.5, 10.5, 15 and 24 months of age. Twelve polymorphisms were genotyped in five oxidative stress pathway genes: glutathione reductase (GSR), glutamylcysteine synthetase (GCLC), glutathione S-transferase (GST) P1, haem oxygenase 1 (HMOX1) and superoxide dismutase 2 (SOD2) in 298 children. There were 284 children assessed for anaemia and clinical malaria infection at the age of 24 months. RESULTS: Two principal components (PCA1 and PCA2) were derived from the AOPP levels measured at the five time points. PCA1 was significantly associated with anaemia (p = 0.0002), and PCA2 with clinical malaria infection (p = 0.047). In the K-Means Cluster Analysis based on levels of AOPP, children were clustered into two groups: Group A (lower AOPP levels) and Group B (higher AOPP levels). The cluster membership was significantly associated with anaemia (p =0.003) as well as with the GSR RS3594 polymorphism (p = 0.037). Mixed linear regression analyses found that the single nucleotide polymorphisms GCLC RS10948751 and HMOX1 RS17885925 were significantly associated with AOPP levels (p = 0.030 and p = 0.027, respectively).CONCLUSION: Plasma AOPP levels were predictive for anaemia and oxidative stress markers for clinical malaria infection in two year old children. Several polymorphisms in GCLC, GSR and HMOX1 genes were associated with oxidative stress status of these children

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