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    Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial

    241195.pdf (655.5Kb)
    Access Status
    Open access
    Authors
    Hambly, J.
    Haywood, A.
    Hattingh, H. Laetitia
    Nair, R.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Hambly, J. and Haywood, A. and Hattingh, H.L. and Nair, R. 2016. Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial. Journal of Investigative and Clinical Dentistry. 8 (3): Article No e12225.
    Source Title
    Journal of Investigative and Clinical Dentistry
    DOI
    10.1111/jicd.12225
    ISSN
    2041-1626
    School
    School of Pharmacy
    Remarks

    This is the peer reviewed version of the following article: Hambly, J. and Haywood, A. and Hattingh, H.L. and Nair, R. 2016. Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial. Journal of Investigative and Clinical Dentistry, 8 (3): Article No e12225, which has been published in final form at http://doi.org/10.1111/jicd.12225 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-828039.html

    URI
    http://hdl.handle.net/20.500.11937/17962
    Collection
    • Curtin Research Publications
    Abstract

    Aim: There is a lack of appropriate, commercially-available topical corticosteroid formulations for use in oral lichen planus (OLP) and oral lichenoid reaction. Current therapy includes crushing a dexamethasone tablet and mixing it with water for use as a mouth rinse. This formulation is unpleasant esthetically and to use in the mouth, as it is a bitter and gritty suspension, resulting in poor compliance. Thus, the present study was designed to formulate and pilot an effective, esthetically-pleasing formulation. Methods: A single-blinded, cross-over trial was designed with two treatment arms. Patients were monitored for 7 weeks. Quantitative and qualitative data was assessed using VAS, numeric pain scales, the Treatment Satisfaction Questionnaire for Medication-9, and thematic analysis to determine primary patient-reported outcomes, including satisfaction, compliance, quality of life, and symptom relief. Results: Nine patients completed the pilot trial. Data analysis revealed the new compounded formulation to be superior to existing therapy due to its convenience, positive contribution to compliance, patient-perceived faster onset of action, and improved symptom relief. Conclusion: Topical dexamethasone is useful in the treatment of OLP. When carefully formulated into a compounded mouth rinse, it improves patient outcomes.

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