Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial
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Aim: There is a lack of appropriate, commercially-available topical corticosteroid formulations for use in oral lichen planus (OLP) and oral lichenoid reaction. Current therapy includes crushing a dexamethasone tablet and mixing it with water for use as a mouth rinse. This formulation is unpleasant esthetically and to use in the mouth, as it is a bitter and gritty suspension, resulting in poor compliance. Thus, the present study was designed to formulate and pilot an effective, esthetically-pleasing formulation. Methods: A single-blinded, cross-over trial was designed with two treatment arms. Patients were monitored for 7 weeks. Quantitative and qualitative data was assessed using VAS, numeric pain scales, the Treatment Satisfaction Questionnaire for Medication-9, and thematic analysis to determine primary patient-reported outcomes, including satisfaction, compliance, quality of life, and symptom relief. Results: Nine patients completed the pilot trial. Data analysis revealed the new compounded formulation to be superior to existing therapy due to its convenience, positive contribution to compliance, patient-perceived faster onset of action, and improved symptom relief. Conclusion: Topical dexamethasone is useful in the treatment of OLP. When carefully formulated into a compounded mouth rinse, it improves patient outcomes.
This is the peer reviewed version of the following article: Hambly, J. and Haywood, A. and Hattingh, H.L. and Nair, R. 2016. Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial. Journal of Investigative and Clinical Dentistry, 8 (3): Article No e12225, which has been published in final form at http://doi.org/10.1111/jicd.12225 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-828039.html
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