Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial
dc.contributor.author | Hambly, J. | |
dc.contributor.author | Haywood, A. | |
dc.contributor.author | Hattingh, H. Laetitia | |
dc.contributor.author | Nair, R. | |
dc.date.accessioned | 2017-01-30T12:05:12Z | |
dc.date.available | 2017-01-30T12:05:12Z | |
dc.date.created | 2016-06-28T19:30:14Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Hambly, J. and Haywood, A. and Hattingh, H.L. and Nair, R. 2016. Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial. Journal of Investigative and Clinical Dentistry. 8 (3): Article No e12225. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/17962 | |
dc.identifier.doi | 10.1111/jicd.12225 | |
dc.description.abstract |
Aim: There is a lack of appropriate, commercially-available topical corticosteroid formulations for use in oral lichen planus (OLP) and oral lichenoid reaction. Current therapy includes crushing a dexamethasone tablet and mixing it with water for use as a mouth rinse. This formulation is unpleasant esthetically and to use in the mouth, as it is a bitter and gritty suspension, resulting in poor compliance. Thus, the present study was designed to formulate and pilot an effective, esthetically-pleasing formulation. Methods: A single-blinded, cross-over trial was designed with two treatment arms. Patients were monitored for 7 weeks. Quantitative and qualitative data was assessed using VAS, numeric pain scales, the Treatment Satisfaction Questionnaire for Medication-9, and thematic analysis to determine primary patient-reported outcomes, including satisfaction, compliance, quality of life, and symptom relief. Results: Nine patients completed the pilot trial. Data analysis revealed the new compounded formulation to be superior to existing therapy due to its convenience, positive contribution to compliance, patient-perceived faster onset of action, and improved symptom relief. Conclusion: Topical dexamethasone is useful in the treatment of OLP. When carefully formulated into a compounded mouth rinse, it improves patient outcomes. | |
dc.title | Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial | |
dc.type | Journal Article | |
dcterms.source.startPage | 1 | |
dcterms.source.endPage | 7 | |
dcterms.source.issn | 2041-1626 | |
dcterms.source.title | Journal of Investigative and Clinical Dentistry | |
curtin.note |
This is the peer reviewed version of the following article: Hambly, J. and Haywood, A. and Hattingh, H.L. and Nair, R. 2016. Comparison between self-formulation and compounded-formation dexamethasone mouth rinse for oral lichen planus: a pilot randomized, cross-over trial. Journal of Investigative and Clinical Dentistry, 8 (3): Article No e12225, which has been published in final form at http://doi.org/10.1111/jicd.12225 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-828039.html | |
curtin.department | School of Pharmacy | |
curtin.accessStatus | Open access |