Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?

Amran, F.; Kim, K.; Lim, A.; Thomson, R.; Lee, S.; Waterer, G.; Price, Patricia

doi:10.1007/s10875-016-0233-1

Access Status

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Authors

Amran, F.

Kim, K.

Lim, A.

Thomson, R.

Lee, S.

Waterer, G.

Price, Patricia

Date

2016

Type

Journal Article

Metadata

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Citation

Amran, F. and Kim, K. and Lim, A. and Thomson, R. and Lee, S. and Waterer, G. and Price, P. 2016. Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? Journal of Clinical Immunology. 36 (2): pp. 113-116.

Source Title

Journal of Clinical Immunology

DOI

10.1007/s10875-016-0233-1

ISSN

0271-9142

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/18652

Collection

Curtin Research Publications

Abstract

© 2016 Springer Science+Business Media New York. Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased.