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Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays

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Authors
Berry, A.
Charles, A.
Zeps, N.
Cregan, D.
Arfuso, Frank
Dharmarajan, Arunasalam
Date
2014
Type
Journal Article

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Berry, A. and Charles, A. and Zeps, N. and Cregan, D. and Arfuso, F. and Dharmarajan, A. 2014. Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays. Journal of Analytical Oncology. 3: pp. 205-212.
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Journal of Analytical Oncology
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School of Biomedical Sciences
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Abstract

Wnt proteins are often up-regulated in cancer. The secreted frizzled-related proteins (sFRPs) can abrogate Wnt signalling and are involved in apoptosis. We investigated the expression of Wnt1, β-Catenin, and an antagonist, sFRP4, as well as apoptosis in breast cancer using tissue micro-arrays (TMAs) comprising 191 tissue cores. Results demonstrated stronger staining intensity for Wnt1 in tumour versus non-tumour samples (p<0.05). Epithelial sFRP4 did not differ between invasive and non-invasive tissue; however, there was increased sFRP4 expression in the blood vessels and lymphocyte cells of tumour compared to non-tumour tissue. These data suggest Wnt involvement in determining the breast cancer phenotype and highlight a potential new role for sFRP4 as a diagnostic/prognostic marker.