Pancreatic cancer: Current research and future directions
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© 2016 Elsevier B.V. Despite the survival rate advancements in different types of cancer in the last 40 years, the perspective for pancreatic cancer patients has seen no substantial changes. Indeed, the five year survival rate remains around 5%. Nevertheless, in the last decade we have witnessed an increased interest in pancreatic cancer biology and this has produced a substantial increment in our knowledge on pancreatic cancer progression. The big challenge is now to translate this knowledge in better outcomes for patients. The aim of this review is to describe the latest discoveries and advancements in pancreatic cancer research and to discuss future directions.
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Schulte, A.; Pandeya, N.; Fawcett, J.; Fritschi, Lin; Klein, K.; Risch, H.; Webb, P.; Whiteman, D.; Neale, R. (2016)PURPOSE: Family history of pancreatic adenocarcinoma is an established risk factor for the disease. However, associations of pancreatic cancer with other familial cancers are less clear. We analyzed data from the Queensland ...
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancerNeale, R.; Clark, P.; Fawcett, J.; Fritschi, Lin; Nagler, B.; Risch, H.; Walters, R.; Crawford, W.; Webb, P.; Whiteman, D.; Buchanan, D. (2014)Pancreatic cancer is a leading cause of cancer-related deaths worldwide. Methylation of DNA may influence risk or be a marker of early disease. The aim of this study was to measure the association between methylation of ...
Tran, B.; Whiteman, D.; Webb, P.; Fritschi, Lin; Fawcett, J.; Risch, H.; Lucas, R.; Pandeya, N.; Schulte, A.; Neale, R. (2013)Background: Ecological studies showing an inverse association between pancreatic cancer incidence and mortality and levels of ultraviolet radiation (UVR), suggest that higher levels of sun exposure may reduce risks of ...