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    Association between human rhinovirus C and severity of acute asthma in children

    Access Status
    Open access via publisher
    Authors
    Bizzintino, J.
    Lee, W.
    Laing, I.
    Vang, F.
    Pappas, T.
    Zhang, Guicheng
    Martin, A.
    Khoo, S.
    Cox, D.
    Geelhoed, G.
    McMinne, P.
    Goldblatt, J.
    Gern, J.
    Le Souëf, P.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Bizzintino, J. and Lee, W. and Laing, I. and Vang, F. and Pappas, T. and Zhang, G. and Martin, A. et al. 2011. Association between human rhinovirus C and severity of acute asthma in children. European Respiratory Journal. 37 (5): pp. 1037-1042.
    Source Title
    European Respiratory Journal
    DOI
    10.1183/09031936.00092410
    ISSN
    0903-1936
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/20131
    Collection
    • Curtin Research Publications
    Abstract

    A new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC), has recently been discovered. We hypothesised that HRVC would be present in children with acute asthma and cause more severe attacks than other viruses or HRV groups. Children with acute asthma (n=128; age 2-16 yrs) were recruited on presentation to an emergency department. Asthma exacerbation severity was assessed, and respiratory viruses and HRV strains were identified in a nasal aspirate. The majority of the children studied had moderate-to-severe asthma (85.2%) and 98.9% were admitted to hospital. HRV was detected in 87.5% and other respiratory viruses in 14.8% of children, most of whom also had HRV. HRVC was present in the majority of children with acute asthma (59.4%) and associated with more severe asthma. Children with HRVC (n=76) had higher asthma severity scores than children whose HRV infection was HRVA or HRVB only (n=34; p=0.018), and all other children (n=50; p=0.016). Of the 19 children with a non-HRV virus, 13 had HRV co-infections, seven of these being HRVC. HRVC accounts for the majority of asthma attacks in children presenting to hospital and causes more severe attacks than previously known HRV groups and other viruses. Copyright©ERS 2011.

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