Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Symptomatic viral infection is associated with impaired response to treatment in children with acute asthma

    Access Status
    Fulltext not available
    Authors
    Rueter, K.
    Bizzintino, J.
    Martin, A.
    Zhang, Guicheng
    Hayden, C.
    Geelhoed, G.
    Goldblatt, J.
    Laing, I.
    Le Souëf, P.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Rueter, K. and Bizzintino, J. and Martin, A. and Zhang, G. and Hayden, C. and Geelhoed, G. and Goldblatt, J. et al. 2012. Symptomatic viral infection is associated with impaired response to treatment in children with acute asthma. Journal of Pediatrics. 160 (1): pp. 82-87.
    Source Title
    Journal of Pediatrics
    DOI
    10.1016/j.jpeds.2011.06.025
    ISSN
    0022-3476
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/44427
    Collection
    • Curtin Research Publications
    Abstract

    Objective: To examine the influence of viral respiratory infection (VRI) on treatment response in acute asthma in children. Study design: A total of 218 children (mean age, 6.6 years) with acute asthma were recruited. Symptoms were recorded, an asthma severity score was determined, and whenever possible, a per-nasal aspirate was obtained for detection of viruses. Each child's response to inhaled ß 2-agonists was assessed after 6, 12, and 24 hours. Results: The 168 children with VRI symptoms received more treatment with inhaled ß 2-agonists after 6 hours (P = .010), 12 hours (P =.002), and 24 hours (P =.0005) compared with the 50 children without such symptoms. Asthma severity did not differ between the 2 groups. A per-nasal aspirate was obtained from 77% of the children. The most frequently identified virus was rhinovirus (61.4%). Among children with symptoms of a VRI, those with rhinovirus had an impaired response to ß 2-agonists at 6 hours (P =.032). Conclusion: Children with acute asthma and symptoms of VRI respond less effectively to ß 2-agonists after 6, 12, or 24 hours and thus may benefit from more intense therapy and monitoring. Copyright © 2012 Mosby Inc. All rights reserved.

    Related items

    Showing items related by title, author, creator and subject.

    • ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma
      Martin, A.; Zhang, Guicheng; Rueter, K.; Khoo, S.; Bizzintino, J.; Hayden, C.; Geelhoed, G.; Goldblatt, J.; Laing, I.; Le Souëf, P. (2008)
      The aim of this study was to determine the influence of single nucleotide polymorphisms in the ß2-adrenoceptor gene, on the response to inhaled ß2-agonists in children with acute asthma. We hypothesised that children with ...
    • An investigation of the current management of asthma in adolescents and children in Saudi Arabia, barriers to optimal care, and the influence of patient education
      Al Thagfan, Sultan Saad (2012)
      The incidence of childhood asthma in the kingdom of Saudi Arabia (KSA) ranges from 4% in some regions to 23% in others. Although international and national guidelines have been issued to improve the management of asthma, ...
    • Frequent nocturnal awakening in early life is associated with nonatopic asthma in children
      Kozyrskyj, A.; Kendall, Garth; Zubrick, Stephen; Newnham, J.; Sly, Peter (2009)
      Frequent nocturnal awakening in early life is associated with nonatopic asthma in children Holdings more options Author(s): Kozyrskyj AL (Kozyrskyj, A. L.)1,2, Kendall GE (Kendall, G. E.)3,4,6, Zubrick SR ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.