Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent
MetadataShow full item record
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of -cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the 1H Nuclear Magnetic Resonance (NMR) relaxation times T1 and T2 allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem®, showed a higher transverse relaxivity for SPIONs@PRs. In vitro MRI experiments showed that our SPIONs@PRs produces better negative contrast compared to Endorem® and can be considered as a novel MRI contrast agent.
Showing items related by title, author, creator and subject.
Synthesis and in vitro evaluation of bone-seeking superparamagnetic iron oxide nanoparticles as contrast agents for imaging bone metabolic activityPanahifar, A.; Mahmoudi, M.; Doschak, Michael (2013)In this article, we report the synthesis and in vitro evaluation of a new class of nonionizing bone-targeting contrast agents based on bisphosphonate-conjugated superparamagnetic iron oxide nanoparticles (SPIONs), for use ...
Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent processLam, U.; Yoganathan, R.; Carr, A.; Mammucari, R.; Foster, Neil (2012)The aim of the experiments in this research was to produce a coated superparamagnetic iron oxide nanoparticle (SPION) product that may be used as a contrasting agent for MRI. There are several methods that can be employed ...
Does genetic distance between parental species influence outcomes of hybridization among coral reef butterflyfishes?Montanari, S.; Hobbs, Jean Paul; Pratchett, M.; Bay, L.; van Herwerden, L. (2014)Christmas Island is located at the overlap of the Indian and Pacific Ocean marine provinces and is a hot spot for marine hybridization. Here, we evaluate the ecological framework and genetic consequences of hybridization ...