Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent
dc.contributor.author | Hosseini, F. | |
dc.contributor.author | Panahifar, A. | |
dc.contributor.author | Adeli, M. | |
dc.contributor.author | Amiri, H. | |
dc.contributor.author | Lascialfari, A. | |
dc.contributor.author | Orsini, F. | |
dc.contributor.author | Doschak, Michael | |
dc.contributor.author | Mahmoudi, M. | |
dc.date.accessioned | 2017-01-30T12:19:08Z | |
dc.date.available | 2017-01-30T12:19:08Z | |
dc.date.created | 2014-02-17T20:00:50Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Hosseini, Forouzan and Panahifar, Arash and Adeli, Mohsen and Amiri, Houshang and Lascialfari, Alessandro and Orsini, Francesco and Doschak, Michael R. and Mahmoudi, Morteza. 2013. Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent. Colloids and Surfaces B: Biointerfaces. 103: pp. 652-657. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/20427 | |
dc.identifier.doi | 10.1016/j.colsurfb.2012.10.035 | |
dc.description.abstract |
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of -cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the 1H Nuclear Magnetic Resonance (NMR) relaxation times T1 and T2 allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem®, showed a higher transverse relaxivity for SPIONs@PRs. In vitro MRI experiments showed that our SPIONs@PRs produces better negative contrast compared to Endorem® and can be considered as a novel MRI contrast agent. | |
dc.publisher | Elsevier BV | |
dc.subject | Nanomedicine | |
dc.subject | MRI contrast agent | |
dc.subject | Supermolecules | |
dc.subject | SPIONs | |
dc.subject | Hybrid nanomaterials | |
dc.subject | Polyrotaxanes | |
dc.title | Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent | |
dc.type | Journal Article | |
dcterms.source.volume | 103 | |
dcterms.source.startPage | 652 | |
dcterms.source.endPage | 657 | |
dcterms.source.issn | 0927-7765 | |
dcterms.source.title | Colloids and Surfaces B: Biointerfaces | |
curtin.department | ||
curtin.accessStatus | Fulltext not available |