HBV-related hepatocellular carcinoma: The role of integration, viral proteins and miRNA

Lim, L. and Tran, B. and Vincan, E. and Locarnini, S. and Warner, N. 2012. HBV-related hepatocellular carcinoma: The role of integration, viral proteins and miRNA. Future Virology. 7 (12): pp. 1237-1249.

Source Title

Future Virology

DOI

10.2217/fvl.12.113

ISSN

1746-0794

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/20581

Collection

Curtin Research Publications

Abstract

The development of hepatocellular carcinoma during chronic hepatitis B infection is a multifactorial process thought to be a consequence of several direct and indirect mechanisms. In this review we discuss how viral proteins and cycles of ongoing liver damage and regeneration, coupled with HBV DNA integration and aberrant miRNA expression may enhance the risk for the development of hepatocellular carcinoma. © 2012 Future Medicine Ltd.