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    HBV-related hepatocellular carcinoma: The role of integration, viral proteins and miRNA

    Access Status
    Fulltext not available
    Authors
    Lim, L.
    Tran, B.
    Vincan, Elizabeth
    Locarnini, S.
    Warner, N.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Lim, L. and Tran, B. and Vincan, E. and Locarnini, S. and Warner, N. 2012. HBV-related hepatocellular carcinoma: The role of integration, viral proteins and miRNA. Future Virology. 7 (12): pp. 1237-1249.
    Source Title
    Future Virology
    DOI
    10.2217/fvl.12.113
    ISSN
    1746-0794
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/20581
    Collection
    • Curtin Research Publications
    Abstract

    The development of hepatocellular carcinoma during chronic hepatitis B infection is a multifactorial process thought to be a consequence of several direct and indirect mechanisms. In this review we discuss how viral proteins and cycles of ongoing liver damage and regeneration, coupled with HBV DNA integration and aberrant miRNA expression may enhance the risk for the development of hepatocellular carcinoma. © 2012 Future Medicine Ltd.

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