Amino acids and diabetes: implications for endocrine, metabolic and immune function
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Authors
Newsholme, Philip
Abdulkader, F.
Rebelato, E.
Romanatto, T.
Pinheiro, C.
Vitzel, K.
Silva, E.
Bazotte, R.
Procopio, J.
Curi, R.
Gorjao, R.
Pithon-Curi, T.
Date
2011Type
Journal Article
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Newsholme, P. and Abdulkader, F. and Rebelato, E. and Romanatto, T. and Pinheiro, C. and Vitzel, K. and Silva, E. et al. 2011. Amino acids and diabetes: implications for endocrine, metabolic and immune function. Frontiers in Bioscience. 16: pp. 315-339.
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Frontiers in Bioscience
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Abstract
Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes.
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