Amino acids and diabetes: implications for endocrine, metabolic and immune function
Access Status
Fulltext not available
Authors
Newsholme, Philip
Abdulkader, F.
Rebelato, E.
Romanatto, T.
Pinheiro, C.
Vitzel, K.
Silva, E.
Bazotte, R.
Procopio, J.
Curi, R.
Gorjao, R.
Pithon-Curi, T.
Date
2011Collection
Type
Journal Article
Metadata
Show full item recordAbstract
Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes.
Citation
Newsholme, P. and Abdulkader, F. and Rebelato, E. and Romanatto, T. and Pinheiro, C. and Vitzel, K. and Silva, E. et al. 2011. Amino acids and diabetes: implications for endocrine, metabolic and immune function. Frontiers in Bioscience. 16: pp. 315-339.
Source Title
Frontiers in Bioscience
DOI
Related items
Showing items related by title, author, creator and subject.
-
Alaei Shahmiri, Fariba (2012)Chronic diseases, such as cardiovascular disease and diabetes, are the leading causes of morbidity and mortality worldwide. Recent studies have shown that in addition to diabetes mellitus, non-diabetic degrees of fasting ...
-
Newsholme, Philip; Cruzat, Vinicius; Arfuso, Frank; Keane, Kevin (2014)Pancreatic ß-cell function is of critical importance in the regulation of fuel homoeostasis, and metabolic dysregulation is a hallmark of diabetes mellitus (DM). The ß-cell is an intricately designed cell type that couples ...
-
Newsholme, Philip; Cruzat, Vinicius; Keane, Kevin; Carlessi, Rodrigo; de Bittencourt, P. (2016)Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative and antioxidative systems of cells and ...