Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria
MetadataShow full item record
Pulmonary disease due to non-tuberculous mycobacteria (NTM) is caused by several species (particularly Mycobacterium avium, Mycobacterium intracellulare) that are abundant in the environment. Th1 cytokines such as interferon (IFN)-γ are important in the control of mycobacteria, but in vitro production of IFN-γ is not deficient in adult patients with pulmonary NTM disease. Antibodies reactive with IFN-γ have been described in patients with disseminated NTM disease, but it is not clear whether they are common in pulmonary disease. Here we show that patients with pulmonary NTM have a higher level of anti-IFN-γ and anti-GM-CSF antibodies than healthy controls, although some controls also have high levels. Levels of anti-IFN-γ antibodies did not correlate with levels of total immunoglobulin. Longitudinal studies are required to determine whether anti-cytokine autoantibodies are consequence rather than a cause of pulmonary NTM disease.
Showing items related by title, author, creator and subject.
Increased CTLA-4+ T cells may contribute to impaired T helper type 1 immune responses in patients with chronic obstructive pulmonary diseaseTan, D.; Teo, T.; Setiawan, A.; Ong, N.; Zimmermann, M.; Price, Patricia; Kirkham, L.; Moodley, Y. (2017)Impaired T helper type 1 (Th1) function is implicated in the susceptibility of patients with chronic obstructive pulmonary disease (COPD) to respiratory infections, which are common causes of acute exacerbations of COPD ...
Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?Amran, F.; Kim, K.; Lim, A.; Thomson, R.; Lee, S.; Waterer, G.; Price, Patricia (2016)© 2016 Springer Science+Business Media New York. Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress ...
TLR2-induced cytokine responses may characterize HIV-infected patients experiencing mycobacterial immune restoration diseaseTan, D.; Lim, A.; Yong, Y.; Ponnampalavanar, S.; Omar, S.; Kamarulzaman, A.; French, M.; Price, Patricia (2011)Objectives: Most HIV patients who experience Mycobacterium tuberculosis-associated immune restoration disease (TB IRD) display elevated interferon-gamma (IFN?) responses against mycobacterial antigens, but these can occur ...