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    Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria

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    Fulltext not available
    Authors
    Kim, K.
    Waterer, G.
    Thomson, R.
    Yang, I.
    Nashi, N.
    Tan, D.
    Price, Patricia
    Date
    2014
    Type
    Journal Article
    
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    Citation
    Kim, K. and Waterer, G. and Thomson, R. and Yang, I. and Nashi, N. and Tan, D. and Price, P. 2014. Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria. Cytokine. 66 (2): pp. 160-163.
    Source Title
    Cytokine
    DOI
    10.1016/j.cyto.2014.01.005
    ISSN
    10434666
    URI
    http://hdl.handle.net/20.500.11937/22117
    Collection
    • Curtin Research Publications
    Abstract

    Pulmonary disease due to non-tuberculous mycobacteria (NTM) is caused by several species (particularly Mycobacterium avium, Mycobacterium intracellulare) that are abundant in the environment. Th1 cytokines such as interferon (IFN)-γ are important in the control of mycobacteria, but in vitro production of IFN-γ is not deficient in adult patients with pulmonary NTM disease. Antibodies reactive with IFN-γ have been described in patients with disseminated NTM disease, but it is not clear whether they are common in pulmonary disease. Here we show that patients with pulmonary NTM have a higher level of anti-IFN-γ and anti-GM-CSF antibodies than healthy controls, although some controls also have high levels. Levels of anti-IFN-γ antibodies did not correlate with levels of total immunoglobulin. Longitudinal studies are required to determine whether anti-cytokine autoantibodies are consequence rather than a cause of pulmonary NTM disease.

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