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    Enzymatic Deracemization of (R,S)-Ibuprofen Ester via Lipase-catalyzed Membrane Reactor

    Access Status
    Fulltext not available
    Authors
    Lau, Sie Yon
    Gonawan, Fadzil
    Kamaruddin, Azlina
    Uzir, Mohamad
    Date
    2013
    Type
    Journal Article
    
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    Citation
    Lau, Sie yon and Gonawan, Fadzil and Kamaruddin, Azlina and Uzir, Mohamad. 2013. Enzymatic Deracemization of (R,S)-Ibuprofen Ester via Lipase-catalyzed Membrane Reactor. Industrial and Engineering Chemistry Research. 52 (27): pp. 9441-9453.
    Source Title
    Industrial and Engineering Chemistry Research
    DOI
    10.1021/ie400795j
    ISSN
    0888-5885
    School
    Sarawak Malaysia
    URI
    http://hdl.handle.net/20.500.11937/22240
    Collection
    • Curtin Research Publications
    Abstract

    Ibuprofen (isobutyl-propanoic-phenolic acid) is a chiral drug which essentially well-known for its analgesic, antipyretic and anti-inflammatory effects. In the present work, an enzymatic membrane reactor (EMR) has been developed for the production of optically pure (S)-ibuprofen acid. The EMR is equipped with a multi-tubular fixed bed racemization unit to enhance the enzymatic deracemization of (R,S)-ibuprofen ester. Several process parameters such as enzyme loading, racemization catalyst loading, reaction temperature, buffer pH as well as the flow rate were investigated. These experimental results were then compared with the proposed process model. It was found that the experimental data were in good agreement with the theoretical results. The optimum condition of the lipase-catalyzed dynamic kinetic resolution (DKR) using the EMR could give 96-98% conversion with 97-99% of product enantiomeric excess (eep).

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