Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology
MetadataShow full item record
(S)-Ibuprofen is a low volume but high value pharmaceutical product which is categorized as non-steroidal anti-inflammatory drug (NSAID). This precious chiral drug may be produced using racemic ibuprofen as raw material through the dynamic kinetic resolution. In this work, a simulation of (S)-ibuprofen production is carried out using ASPEN PLUS ® process simulation software. A pilot scale production with the capacity of 500g/day of (S)-ibuprofen acid is considered in the present study. The product is synthesized through a three-step process: (i) substrate preparation via esterification; (ii) enzymatic dynamic kinetic resolution of substrate ester and (iii) product purification. Mass and energy balances of major equipment were calculated. The performance of the enzyme-mediated membrane reactor (EMR) was investigated by manipulating substrate and base concentrations as well as the flow rates. Besides, a number of issues related to the evaporation and crystallization of the product were identified and addressed. It was found that the optimum operating condition of EMR at 40°C, 50-100ml/min lumen flow rate with substrate and base concentrations, respectively at 10-20mM and 60-100mM, gave 0.92 conversion and 0.9 ee p of the product. An overall yield of 82.5% product crystal was achieved by operating the cooling-crystallizer in the temperature range of 5-10°C. © 2010 Elsevier B.V.
Showing items related by title, author, creator and subject.
Kamaruddin, A.; Uzir, M.; Gonawan, F.; Lau, John (2015)© Springer International Publishing Switzerland 2015. The optical purity of non-steriodal anti-inflammatory drugs (NSAIDs) is one of the concerns in pharmaceutical industries, since the enantiomers demonstrate distinct ...
Effect of co-solvent addition on the reaction kinetics of the lipase-catalyzed resolution of ibuprofen esterGonawan, Fadzil; Lau, John; Kamaruddin, Azlina; Uzir, Mohamad (2013)BACKGROUND: The addition of co-solvent is not limited to enhancing the catalytic rate, it could also assist in situ racemization in the dynamic kinetic resolution of racemic compounds by increasing the reactivity of the ...
Lau, Sie Yon; Gonawan, Fadzil; Kamaruddin, Azlina; Uzir, Mohamad (2013)Ibuprofen (isobutyl-propanoic-phenolic acid) is a chiral drug which essentially well-known for its analgesic, antipyretic and anti-inflammatory effects. In the present work, an enzymatic membrane reactor (EMR) has been ...