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    Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology

    Access Status
    Fulltext not available
    Authors
    Lau, John
    Gonawan, F.
    Bhatia, S.
    Kamaruddin, A.
    Uzir, M.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Lau, J. and Gonawan, F. and Bhatia, S. and Kamaruddin, A. and Uzir, M. 2011. Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology. Chemical Engineering Journal. 166 (2): pp. 726-737.
    Source Title
    Chemical Engineering Journal
    DOI
    10.1016/j.cej.2010.11.072
    ISSN
    1385-8947
    School
    Curtin Malaysia
    URI
    http://hdl.handle.net/20.500.11937/68117
    Collection
    • Curtin Research Publications
    Abstract

    (S)-Ibuprofen is a low volume but high value pharmaceutical product which is categorized as non-steroidal anti-inflammatory drug (NSAID). This precious chiral drug may be produced using racemic ibuprofen as raw material through the dynamic kinetic resolution. In this work, a simulation of (S)-ibuprofen production is carried out using ASPEN PLUS ® process simulation software. A pilot scale production with the capacity of 500g/day of (S)-ibuprofen acid is considered in the present study. The product is synthesized through a three-step process: (i) substrate preparation via esterification; (ii) enzymatic dynamic kinetic resolution of substrate ester and (iii) product purification. Mass and energy balances of major equipment were calculated. The performance of the enzyme-mediated membrane reactor (EMR) was investigated by manipulating substrate and base concentrations as well as the flow rates. Besides, a number of issues related to the evaporation and crystallization of the product were identified and addressed. It was found that the optimum operating condition of EMR at 40°C, 50-100ml/min lumen flow rate with substrate and base concentrations, respectively at 10-20mM and 60-100mM, gave 0.92 conversion and 0.9 ee p of the product. An overall yield of 82.5% product crystal was achieved by operating the cooling-crystallizer in the temperature range of 5-10°C. © 2010 Elsevier B.V.

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      Ibuprofen (isobutyl-propanoic-phenolic acid) is a chiral drug which essentially well-known for its analgesic, antipyretic and anti-inflammatory effects. In the present work, an enzymatic membrane reactor (EMR) has been ...
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