Lifetime physical activity and risk of breast cancer in pre-and post-menopausal women
MetadataShow full item record
The final publication is available at Springer via http://doi.org/10.1007/s10549-015-3489-x
© 2015 Springer Science+Business Media New York To investigate the association between different types of physical activity (PA) and breast cancer. A case–control study of breast cancer was conducted in Western Australia from 2009 to 2011, in which 1205 women with breast cancer and 1789 frequency age-matched breast cancer-free control women were recruited. A self-administered questionnaire was used to collect information about lifetime and age-period recreational, household, occupational and transport physical activities. Detailed questions about demographic characteristics, and relevant reproductive, medical and lifestyle factors were also included. Logistic regression and restrictive cubic spline analyses were applied to investigate the association and dose–response relationship between PA and breast cancer risk. Subgroup analysis was performed regarding menopausal status. We found non-linear dose–response associations between PA and risk of breast cancer. Overall, 95–130 MET-hours/week of total lifetime PA was associated with the lowest breast cancer risk. The effects were stronger among post-menopausal women. We also found that the medium amounts of recreational PA (up to 21 MET-hours/week) were associated with lower breast cancer risk among post-menopausal women. Further analysis on the intensity of recreational PA demonstrated different dose–response associations between moderate- and vigorous-intensity recreational PA and breast cancer risk. We found that PA was associated with a reduced risk of breast cancer among post-menopausal women, but not in a linear fashion. Recreational PA of different intensities may have different dose–response associations with risk of breast cancer.
Showing items related by title, author, creator and subject.
Night shift work and breast cancer: a pooled analysis of population-based case–control studies with complete work historyCordina-Duverger, E.; Menegaux, F.; Popa, A.; Rabstein, S.; Harth, V.; Pesch, B.; Brüning, T.; Fritschi, Lin; Glass, D.; Heyworth, J.; Erren, T.; Castaño-Vinyals, G.; Papantoniou, K.; Espinosa, A.; Kogevinas, M.; Grundy, A.; Spinelli, J.; Aronson, K.; Guénel, P. (2018)© 2018 Springer Science+Business Media B.V., part of Springer Nature Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment ...
Women commencing anastrozole, letrozole or tamoxifen for early breast cancer: The impact of comorbidity and demographics on initial choiceKemp, A.; Preen, D.; Saunders, C.; Boyle, F.; Bulsara, M.; Holman, C.; Malacova, Eva; Roughead, E. (2014)Background: Australian clinical guidelines recommend endocrine therapy for all women with hormone-dependent early breast cancer. Guidelines specify tamoxifen as first-line therapy for pre-menopausal women, and tamoxifen ...
Comparison of anthropometric measures as predictors of cancer incidence: A pooled collaborative analysis of 11 Australian cohortsHarding, J.; Shaw, J.; Anstey, K.; Adams, R.; Balkau, B.; Brennan-Olsen, S.; Briffa, T.; Davis, T.; Davis, W.; Dobson, A.; Flicker, L.; Giles, G.; Grant, J.; Huxley, R.; Knuiman, M.; Luszcz, M.; MacInnis, R.; Mitchell, P.; Pasco, J.; Reid, Christopher; Simmons, D.; Simons, L.; Tonkin, A.; Woodward, M.; Peeters, A.; Magliano, D. (2015)Obesity is a risk factor for cancer. However, it is not known if general adiposity, as measured by body mass index (BMI) or central adiposity [e.g., waist circumference (WC)] have stronger associations with cancer, or ...