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    Night shift work and breast cancer: a pooled analysis of population-based case–control studies with complete work history

    66506.pdf (401.5Kb)
    Access Status
    Open access
    Authors
    Cordina-Duverger, E.
    Menegaux, F.
    Popa, A.
    Rabstein, S.
    Harth, V.
    Pesch, B.
    Brüning, T.
    Fritschi, Lin
    Glass, D.
    Heyworth, J.
    Erren, T.
    Castaño-Vinyals, G.
    Papantoniou, K.
    Espinosa, A.
    Kogevinas, M.
    Grundy, A.
    Spinelli, J.
    Aronson, K.
    Guénel, P.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Cordina-Duverger, E. and Menegaux, F. and Popa, A. and Rabstein, S. and Harth, V. and Pesch, B. and Brüning, T. et al. 2018. Night shift work and breast cancer: a pooled analysis of population-based case–control studies with complete work history. European Journal of Epidemiology: pp. 1-11.
    Source Title
    European Journal of Epidemiology
    DOI
    10.1007/s10654-018-0368-x
    ISSN
    0393-2990
    School
    School of Public Health
    Remarks

    This is a post-peer-review, pre-copyedit version of an article published in European Journal of Epidemiology. The final authenticated version is available online at: http://doi.org/10.1007/s10654-018-0368-x.

    URI
    http://hdl.handle.net/20.500.11937/66305
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Springer Science+Business Media B.V., part of Springer Nature

    Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case–control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a.m. as compared to never night workers was 1.12 (95% CI 1.00–1.25). Among pre-menopausal women, this odds ratio was 1.26 [1.06–1.51], increasing to 1.36 [1.07–1.74] for night shifts = 10 h, 1.80 [1.20–2.71] for work = 3 nights/week, and 2.55 [1.03–6.30] for both duration of night work = 10 years and exposure intensity = 3 nights/week. Breast cancer risk in pre-menopausal women was higher in current or recent night workers (OR = 1.41 [1.06–1.88]) than in those who had stopped night work more than 2 years ago. Breast cancer in post-menopausal women was not associated with night work whatever the exposure metric. The increase in risk was restricted to ER+ tumors, particularly those who were both ER+ and HER2+ . These results support the hypothesis that night shift work increases the risk of breast cancer in pre-menopausal women, particularly those with high intensity and long duration of exposure. Risk difference between pre- and post-menopausal women deserves further scrutiny.

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