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    Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children

    Access Status
    Fulltext not available
    Authors
    Morahan, G.
    Huang, D.
    Wu, M.
    Holt, B.
    White, G.
    Kendall, Garth
    Sly, Peter
    Holt, P.
    Date
    2002
    Type
    Journal Article
    
    Metadata
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    Citation
    Morahan, Grant and Huang, Dexing and Wu, Mark and Holt, Barbara J. and White, Gregory P. and Kendall, Garth E. and Sly, Peter D. and Holt, Patrick G.. 2002. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 360 (9331): 455-459.
    Source Title
    Lancet
    DOI
    10.1016/S0140-6736(02)09676-9
    Faculty
    School of Nursing and Midwifery
    Division of Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/22722
    Collection
    • Curtin Research Publications
    Abstract

    Background Severe asthma is a frequent cause of hospital admission, especially among children. The main environmental triggers of airway inflammation in asthma are viruses and aeroallergens. These agents elicit reciprocal immune responses, characterised by production of T helper 1 and T helper 2 cytokines, respectively. There is no genetic explanation for how hyper-responsiveness to these disparate environmental stimuli develops among individuals with asthma. Our aim was to assess relation between an IL12B promoter polymorphism and asthma.

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