Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children
MetadataShow full item record
Background Severe asthma is a frequent cause of hospital admission, especially among children. The main environmental triggers of airway inflammation in asthma are viruses and aeroallergens. These agents elicit reciprocal immune responses, characterised by production of T helper 1 and T helper 2 cytokines, respectively. There is no genetic explanation for how hyper-responsiveness to these disparate environmental stimuli develops among individuals with asthma. Our aim was to assess relation between an IL12B promoter polymorphism and asthma.
Morahan, Grant and Huang, Dexing and Wu, Mark and Holt, Barbara J. and White, Gregory P. and Kendall, Garth E. and Sly, Peter D. and Holt, Patrick G. (2002) Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children, Lancet 360(9331):455-459.
The link to this article is:
Copyright 2002 Elsevier B.V. All rights reserved
Showing items related by title, author, creator and subject.
Turner, Sian Elizabeth (2009)Background and research questions. The characterization of chronic persistent asthma in an older adult population is not well defined. This is due to the difficulties in separating the diagnosis of asthma from that of ...
An investigation of the current management of asthma in adolescents and children in Saudi Arabia, barriers to optimal care, and the influence of patient educationAl Thagfan, Sultan Saad (2012)The incidence of childhood asthma in the kingdom of Saudi Arabia (KSA) ranges from 4% in some regions to 23% in others. Although international and national guidelines have been issued to improve the management of asthma, ...
Kozyrskyj, A.; Kendall, Garth; Zubrick, Stephen; Newnham, J.; Sly, Peter (2009)Frequent nocturnal awakening in early life is associated with nonatopic asthma in children Holdings more options Author(s): Kozyrskyj AL (Kozyrskyj, A. L.)1,2, Kendall GE (Kendall, G. E.)3,4,6, Zubrick SR ...