Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children
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Authors
Morahan, G.
Huang, D.
Wu, M.
Holt, B.
White, G.
Kendall, Garth
Sly, Peter
Holt, P.
Date
2002Type
Journal Article
Metadata
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Morahan, Grant and Huang, Dexing and Wu, Mark and Holt, Barbara J. and White, Gregory P. and Kendall, Garth E. and Sly, Peter D. and Holt, Patrick G.. 2002. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 360 (9331): 455-459.
Source Title
Lancet
Faculty
School of Nursing and Midwifery
Division of Health Sciences
Collection
Abstract
Background Severe asthma is a frequent cause of hospital admission, especially among children. The main environmental triggers of airway inflammation in asthma are viruses and aeroallergens. These agents elicit reciprocal immune responses, characterised by production of T helper 1 and T helper 2 cytokines, respectively. There is no genetic explanation for how hyper-responsiveness to these disparate environmental stimuli develops among individuals with asthma. Our aim was to assess relation between an IL12B promoter polymorphism and asthma.
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