Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children
| dc.contributor.author | Morahan, G. | |
| dc.contributor.author | Huang, D. | |
| dc.contributor.author | Wu, M. | |
| dc.contributor.author | Holt, B. | |
| dc.contributor.author | White, G. | |
| dc.contributor.author | Kendall, Garth | |
| dc.contributor.author | Sly, Peter | |
| dc.contributor.author | Holt, P. | |
| dc.date.accessioned | 2017-01-30T12:33:13Z | |
| dc.date.available | 2017-01-30T12:33:13Z | |
| dc.date.created | 2008-11-12T23:36:41Z | |
| dc.date.issued | 2002 | |
| dc.identifier.citation | Morahan, Grant and Huang, Dexing and Wu, Mark and Holt, Barbara J. and White, Gregory P. and Kendall, Garth E. and Sly, Peter D. and Holt, Patrick G.. 2002. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 360 (9331): 455-459. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/22722 | |
| dc.identifier.doi | 10.1016/S0140-6736(02)09676-9 | |
| dc.description.abstract |
Background Severe asthma is a frequent cause of hospital admission, especially among children. The main environmental triggers of airway inflammation in asthma are viruses and aeroallergens. These agents elicit reciprocal immune responses, characterised by production of T helper 1 and T helper 2 cytokines, respectively. There is no genetic explanation for how hyper-responsiveness to these disparate environmental stimuli develops among individuals with asthma. Our aim was to assess relation between an IL12B promoter polymorphism and asthma. | |
| dc.publisher | Elsevier | |
| dc.title | Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children | |
| dc.type | Journal Article | |
| dcterms.source.volume | 360 | |
| dcterms.source.number | 9331 | |
| dcterms.source.month | aug | |
| dcterms.source.startPage | 455 | |
| dcterms.source.endPage | 459 | |
| dcterms.source.title | Lancet | |
| curtin.identifier | EPR-3083 | |
| curtin.accessStatus | Fulltext not available | |
| curtin.faculty | School of Nursing and Midwifery | |
| curtin.faculty | Division of Health Sciences |