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    IgG Responses to Pneumococcal and Haemophilus Influenzae Protein Antigens Are Not Impaired in Children with a History of Recurrent Acute Otitis Media

    Access Status
    Open access via publisher
    Authors
    Wiertsema, S.
    Corscadden, K.
    Mowe, E.
    Zhang, Guicheng
    Vijayasekaran, S.
    Coates, H.
    Mitchell, T.
    Thomas, W.
    Richmond, P.
    Kirkham, L.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Wiertsema, S. and Corscadden, K. and Mowe, E. and Zhang, G. and Vijayasekaran, S. and Coates, H. and Mitchell, T. et al. 2012. IgG Responses to Pneumococcal and Haemophilus Influenzae Protein Antigens Are Not Impaired in Children with a History of Recurrent Acute Otitis Media. PLoS ONE. 7 (11).
    Source Title
    PLoS ONE
    DOI
    10.1371/journal.pone.0049061
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/22817
    Collection
    • Curtin Research Publications
    Abstract

    Background: Vaccines including conserved antigens from Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) have the potential to reduce the burden of acute otitis media. Little is known about the antibody response to such antigens in young children with recurrent acute otitis media, however, it has been suggested antibody production may be impaired in these children. Methods: We measured serum IgG levels against 4 pneumococcal (PspA1, PspA 2, CbpA and Ply) and 3 NTHi (P4, P6 and PD) proteins in a cross-sectional study of 172 children under 3 years of age with a history of recurrent acute otitis media (median 7 episodes, requiring ventilation tube insertion) and 63 healthy age-matched controls, using a newly developed multiplex bead assay. Results: Children with a history of recurrent acute otitis media had significantly higher geometric mean serum IgG levels against NTHi proteins P4, P6 and PD compared with healthy controls, whereas there was no difference in antibody levels against pneumococcal protein antigens. In both children with and without a history of acute otitis media, antibody levels increased with age and were significantly higher in children colonised with S. pneumoniae or NTHi compared with children that were not colonised. Conclusions: Proteins from S. pneumoniae and NTHi induce serum IgG in children with a history of acute otitis media. The mechanisms in which proteins induce immunity and potential protection requires further investigation but the dogma of impaired antibody responses in children with recurrent acute otitis media should be reconsidered. © 2012 Wiertsema et al.

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