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    CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages

    Access Status
    Fulltext not available
    Authors
    Dave, R.
    Hume, D.
    Elsegood, Caryn
    Kellie, S.
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Dave, R. and Hume, D. and Elsegood, C. and Kellie, S. 2009. CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Experimental Cell Research. 315 (10): pp. 1734-1744.
    Source Title
    Experimental Cell Research
    DOI
    10.1016/j.yexcr.2009.02.023
    ISSN
    0014-4827
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/22836
    Collection
    • Curtin Research Publications
    Abstract

    In macrophages, tyrosine phosphorylation regulates many signalling pathways leading to growth, differentiation, activation, phagocytosis and adhesion. Protein tyrosine phosphatases (PTPs) represent a biochemical counterbalance to the activity of protein tyrosine kinases, thus regulating the dynamic phosphorylation state of a cell. CD148 is a receptor PTP that is highly expressed in macrophages and is further regulated by pro-inflammatory stimuli. CD148 is normally localised to the plasma membrane of macrophages. Following stimulation with CSF-1 or LPS, there was a re-distribution and concentration of CD148 in areas of membrane ruffling. Treatment of macrophages with anti-CD148 monoclonal antibody inhibited CSF-1-induced macrophage spreading, cytoskeletal re-arrangements and chemotaxis, without affecting cell survival. There were no detectable effects on the CSF-1 receptor-akt signalling pathway. These results are consistent with the hypothesis that CD148 is a regulator of macrophage activity. © 2009 Elsevier Inc. All rights reserved.

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