Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans
MetadataShow full item record
The in vitro gastrointestinal stability of (poly)phenolic compounds in Concord grape juice was compared with recoveries in ileal fluid after the ingestion of the juice by ileostomists. Recoveries in ileal fluid indicated that 67% of hydroxycinnamate tartarate esters, and smaller percentages of the intake of other (poly)phenolic compounds, pass from the small intestine to the colon. The juice was also ingested by healthy subjects with an intact functioning colon. Peak plasma concentrations (C max) ranged from 1.0 nmol/L for petunidin-3-O-glucoside to 355 nmol/L for dihydrocoumaric acid. Urinary excretion, as an indicator of bioavailability, varied from 0.26% for total anthocyanins to 24% for metabolites of hydroxycinnamate tartarate esters. The C max times of the anthocyanins indicated that their low level absorption occurred in the small intestine in contrast to hydroxycinnamate metabolites which were absorbed in both the small and the large intestine where the colonic microflora appeared responsible for hydrogenation of the hydroxycinnamate side chain. The bioavailability of the complex mixture of (poly)phenolic compounds in Concord grape juice, was very similar to that observed in previous studies when compounds were either fed individually or as major components in products containing a restricted spectrum of (poly)phenolic compounds. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Showing items related by title, author, creator and subject.
Identification of (Poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumptionStalmach, A.; Edwards, Christine; Wightman, J.; Crozier, A. (2011)Analysis of Concord grape juice by HPLC with ESI-MSn, PDA, and fluorescence detection resulted in the identification and quantification of 60 flavonoids and related phenolic compounds, which were present at an overall ...
Stalmach, A.; Edwards, Christine; Wightman, J.; Crozier, A. (2013)After acute ingestion of 350 ml of Concord grape juice, containing 528 µmol of (poly)phenolic compounds, by healthy volunteers, a wide array of phase I and II metabolites were detected in the circulation and excreted in ...
Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trialMullan, A.; Delles, C.; Ferrell, W.; Mullen, W.; Edwards, Christine; McColl, J.; Roberts, S.; Lean, M.; Sattar, N. (2016)© 2016 . Objective: To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function ...