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    Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans

    Access Status
    Fulltext not available
    Authors
    Stalmach, A.
    Edwards, Christine
    Wightman, J.
    Crozier, A.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Stalmach, A. and Edwards, C. and Wightman, J. and Crozier, A. 2012. Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans. Molecular Nutrition and Food Research. 56 (3): pp. 497-509.
    Source Title
    Molecular Nutrition and Food Research
    DOI
    10.1002/mnfr.201100566
    ISSN
    1613-4125
    URI
    http://hdl.handle.net/20.500.11937/23056
    Collection
    • Curtin Research Publications
    Abstract

    The in vitro gastrointestinal stability of (poly)phenolic compounds in Concord grape juice was compared with recoveries in ileal fluid after the ingestion of the juice by ileostomists. Recoveries in ileal fluid indicated that 67% of hydroxycinnamate tartarate esters, and smaller percentages of the intake of other (poly)phenolic compounds, pass from the small intestine to the colon. The juice was also ingested by healthy subjects with an intact functioning colon. Peak plasma concentrations (C max) ranged from 1.0 nmol/L for petunidin-3-O-glucoside to 355 nmol/L for dihydrocoumaric acid. Urinary excretion, as an indicator of bioavailability, varied from 0.26% for total anthocyanins to 24% for metabolites of hydroxycinnamate tartarate esters. The C max times of the anthocyanins indicated that their low level absorption occurred in the small intestine in contrast to hydroxycinnamate metabolites which were absorbed in both the small and the large intestine where the colonic microflora appeared responsible for hydrogenation of the hydroxycinnamate side chain. The bioavailability of the complex mixture of (poly)phenolic compounds in Concord grape juice, was very similar to that observed in previous studies when compounds were either fed individually or as major components in products containing a restricted spectrum of (poly)phenolic compounds. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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      After acute ingestion of 350 ml of Concord grape juice, containing 528 µmol of (poly)phenolic compounds, by healthy volunteers, a wide array of phase I and II metabolites were detected in the circulation and excreted in ...
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      Mullan, A.; Delles, C.; Ferrell, W.; Mullen, W.; Edwards, Christine; McColl, J.; Roberts, S.; Lean, M.; Sattar, N. (2016)
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