Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial

    Access Status
    Fulltext not available
    Authors
    Mullan, A.
    Delles, C.
    Ferrell, W.
    Mullen, W.
    Edwards, Christine
    McColl, J.
    Roberts, S.
    Lean, M.
    Sattar, N.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Mullan, A. and Delles, C. and Ferrell, W. and Mullen, W. and Edwards, C. and McColl, J. and Roberts, S. et al. 2016. Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial. Atherosclerosis. 246: pp. 169-176.
    Source Title
    Atherosclerosis
    DOI
    10.1016/j.atherosclerosis.2016.01.004
    ISSN
    0021-9150
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/62767
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 . Objective: To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function in middle aged, overweight or obese subjects without medical co-morbidity in a randomized placebo controlled pilot study. Methods: Randomly assigned active 250 ml beverages containing 361 mg of (poly)phenols and 120 mg of vitamin C or placebo (no polyphenol/vitamin C) were taken twice daily for 4 weeks. Both beverages contained 40 kcals/250 ml. The primary end-points were pulse wave velocity (PWV) and cutaneous microvascular responses to sodium nitroprusside (SNP) and acetyl choline (ACh) laser doppler iontophoresis. A range of established and novel plasma markers were also measured. Results: Twenty subjects received active beverage and 19 placebo; all completed the study. There was no difference in cutaneous vascular response to either SNP or ACh with mean group differences (logd area under perfusion curve) of 0.30 (-0.65, 1.26) and 0.35 (-0.11, 0.81) respectively. Nor was there evidence of a change in log PWV with a mean group difference of 0.029 m/s (-0.042, 0.10). No significant differences were seen in plasma leptin, apolipoproteins, cystatin C, insulin, adiponectin, CRP, ICAM-1, E-Selectin or t-PA, but IL-6 increased in active versus placebo recipients (0.32 vs - 0.18 pg/ml; p = 0.010). Conculsion: There was no evidence for a short-term beneficial effect of (poly)phenol intervention on microcutaneous vascular response or pulse wave velocity, and no evidence for a benefit on established or novel risk factors in overweight or obese subjects. Our results do not support a short-term benefit of (poly)phenol supplementation on cardiometabolic risk.Registration: Clinical Trials.gov (NCT00795834).

    Related items

    Showing items related by title, author, creator and subject.

    • Colonic catabolism of dietary phenolic and polyphenolic compounds from Concord grape juice
      Stalmach, A.; Edwards, Christine; Wightman, J.; Crozier, A. (2013)
      After acute ingestion of 350 ml of Concord grape juice, containing 528 µmol of (poly)phenolic compounds, by healthy volunteers, a wide array of phase I and II metabolites were detected in the circulation and excreted in ...
    • The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers
      Boon, E.; Croft, K.; Shinde, S.; Hodgson, J.; Ward, Natalie (2017)
      © 2017 The Royal Society of Chemistry. A diet rich in plant polyphenols has been suggested to reduce the incidence of cardiovascular disease and type 2 diabetes mellitus, in part, via improvements in endothelial function. ...
    • Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans
      Stalmach, A.; Edwards, Christine; Wightman, J.; Crozier, A. (2012)
      The in vitro gastrointestinal stability of (poly)phenolic compounds in Concord grape juice was compared with recoveries in ileal fluid after the ingestion of the juice by ileostomists. Recoveries in ileal fluid indicated ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.