An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations
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Authors
Mooranian, A.
Negrulj, R.
Mathavan, S.
Martinez, J.
Sciarretta, J.
Chen-Tan, N.
Mukkur, T.
Mikov, M.
Lalic-Popovic, M.
Stojancevic, M.
Golocorbin-Kon, S.
Al-Salami, Hani
Date
2015Type
Journal Article
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Mooranian, A. and Negrulj, R. and Mathavan, S. and Martinez, J. and Sciarretta, J. and Chen-Tan, N. and Mukkur, T. et al. 2015. An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations. Pharmaceutical Development and Technology. 20 (6): pp. 702-709.
Source Title
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
ISSN
School
School of Pharmacy
Collection
Abstract
In previous studies, we have shown that a gliclazide-cholic acid derivative (G-CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G-CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also aim to examine the effect of CA addition to G microcapsules in the morphology, structure and excipients' compatibility of the newly designed microcapsules.