An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations
dc.contributor.author | Mooranian, A. | |
dc.contributor.author | Negrulj, R. | |
dc.contributor.author | Mathavan, S. | |
dc.contributor.author | Martinez, J. | |
dc.contributor.author | Sciarretta, J. | |
dc.contributor.author | Chen-Tan, N. | |
dc.contributor.author | Mukkur, T. | |
dc.contributor.author | Mikov, M. | |
dc.contributor.author | Lalic-Popovic, M. | |
dc.contributor.author | Stojancevic, M. | |
dc.contributor.author | Golocorbin-Kon, S. | |
dc.contributor.author | Al-Salami, Hani | |
dc.date.accessioned | 2017-01-30T12:35:55Z | |
dc.date.available | 2017-01-30T12:35:55Z | |
dc.date.created | 2015-12-10T04:25:56Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Mooranian, A. and Negrulj, R. and Mathavan, S. and Martinez, J. and Sciarretta, J. and Chen-Tan, N. and Mukkur, T. et al. 2015. An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations. Pharmaceutical Development and Technology. 20 (6): pp. 702-709. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/23183 | |
dc.identifier.doi | 10.3109/10837450.2014.915570 | |
dc.description.abstract |
In previous studies, we have shown that a gliclazide-cholic acid derivative (G-CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G-CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also aim to examine the effect of CA addition to G microcapsules in the morphology, structure and excipients' compatibility of the newly designed microcapsules. | |
dc.publisher | TAYLOR & FRANCIS LTD | |
dc.title | An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations | |
dc.type | Journal Article | |
dcterms.source.volume | 20 | |
dcterms.source.number | 6 | |
dcterms.source.startPage | 702 | |
dcterms.source.endPage | 709 | |
dcterms.source.issn | 1083-7450 | |
dcterms.source.title | PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | |
curtin.department | School of Pharmacy | |
curtin.accessStatus | Fulltext not available |
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