Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum
MetadataShow full item record
The original publication is available at: http://www.springerlink.com
A recent comparative proteomics study identified the short-chain dehydrogenase (Sch1) as being required for asexual sporulation (Tan et al. Eukaryotic Cell 7:1916–1929, 2008). Metabolite profiling was undertaken on the mutant strains of Stagonospora nodorum lacking the Sch1 gene to help elucidate its role. Gas chromatography-mass spectrometry of the polar metabolites in the Sch1 mutants identified a secondary metabolite at a 200-fold greater concentration than observed in the wild-type strains. Comparative analysis of the secondary metabolite and the mycotoxin alternariol using ESI-MS/MS confirmed the identity of the compound as alternariol. This is the first report to confirm the presence of a mycotoxin in S. nodorum and compelling the field to consider the health implication of this disease.
Showing items related by title, author, creator and subject.
The Transcription Factor SnStuA Regulates Central Carbon Metabolism, Mycotoxin production and Host-Specific Toxin Expression in the Wheat Pathogen Stagonospora nodorumIp-Cho, S.; Tan, Kar-Chun; Koh, G.; Oliver, Richard; Trengove, R.; Solomon, P. (2010)The Stagonospora nodorum StuA transcription factor gene SnStuA was identified by homology searching in the genome of the wheat pathogen Stagonospora nodorum. Gene expression analysis revealed that SnStuA transcript abundance ...
SnPKS19 encodes the polyketide synthase for alternariol mycotoxin biosynthesis in the wheat pathogen Parastagonospora nodorumChooi, Y.; Muria-González, Mariano Jordi; Mead, O.; Solomon, P. (2015)© 2015, American Society for Microbiology.Alternariol (AOH) is an important mycotoxin from the Alternaria fungi. AOH was detected for the first time in the wheat pathogen Parastagonospora nodorum in a recent study. Here, ...
Dissecting the role of G-protein signalling in primary metabolism in the wheat pathogen Stagonospora nodorumGummer, J.; Trengove, R.; Oliver, Richard; Solomon, P. (2013)Mutants of the wheat pathogenic fungus Stagonospora nodorum lacking G-protein subunits display a variety of phenotypes including melanization defects, primary metabolic changes and a decreased ability to sporulate. To ...