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    Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum

    154877_154877.pdf (102.9Kb)
    Access Status
    Open access
    Authors
    Tan, Kar-Chun
    Trengove, R.
    Maker, G.
    Oliver, Richard
    Solomon, P.
    Date
    2009
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Tan, Kar-Chun and Trengove, Robert D. and Maker, Garth L. and Oliver, Richard P. and Solomon, Peter S. 2009. Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum. Metabolomics. 5 (3): pp. 330-335.
    Source Title
    Metabolomics
    DOI
    10.1007/s11306-009-0158-2
    ISSN
    1573-3890
    School
    Department of Environment and Agriculture
    Remarks

    The original publication is available at: http://www.springerlink.com

    URI
    http://hdl.handle.net/20.500.11937/23652
    Collection
    • Curtin Research Publications
    Abstract

    A recent comparative proteomics study identified the short-chain dehydrogenase (Sch1) as being required for asexual sporulation (Tan et al. Eukaryotic Cell 7:1916–1929, 2008). Metabolite profiling was undertaken on the mutant strains of Stagonospora nodorum lacking the Sch1 gene to help elucidate its role. Gas chromatography-mass spectrometry of the polar metabolites in the Sch1 mutants identified a secondary metabolite at a 200-fold greater concentration than observed in the wild-type strains. Comparative analysis of the secondary metabolite and the mycotoxin alternariol using ESI-MS/MS confirmed the identity of the compound as alternariol. This is the first report to confirm the presence of a mycotoxin in S. nodorum and compelling the field to consider the health implication of this disease.

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