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dc.contributor.authorTan, Kar-Chun
dc.contributor.authorTrengove, R.
dc.contributor.authorMaker, G.
dc.contributor.authorOliver, Richard
dc.contributor.authorSolomon, P.
dc.date.accessioned2017-01-30T12:38:31Z
dc.date.available2017-01-30T12:38:31Z
dc.date.created2011-03-22T20:01:37Z
dc.date.issued2009
dc.identifier.citationTan, Kar-Chun and Trengove, Robert D. and Maker, Garth L. and Oliver, Richard P. and Solomon, Peter S. 2009. Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum. Metabolomics. 5 (3): pp. 330-335.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/23652
dc.identifier.doi10.1007/s11306-009-0158-2
dc.description.abstract

A recent comparative proteomics study identified the short-chain dehydrogenase (Sch1) as being required for asexual sporulation (Tan et al. Eukaryotic Cell 7:1916–1929, 2008). Metabolite profiling was undertaken on the mutant strains of Stagonospora nodorum lacking the Sch1 gene to help elucidate its role. Gas chromatography-mass spectrometry of the polar metabolites in the Sch1 mutants identified a secondary metabolite at a 200-fold greater concentration than observed in the wild-type strains. Comparative analysis of the secondary metabolite and the mycotoxin alternariol using ESI-MS/MS confirmed the identity of the compound as alternariol. This is the first report to confirm the presence of a mycotoxin in S. nodorum and compelling the field to consider the health implication of this disease.

dc.publisherSpringer Science+Business Media
dc.subjectPathogen
dc.subjectStagonospora nodorum
dc.subjectMycotoxin
dc.subjectAlternariol
dc.subjectMetabolomics
dc.titleMetabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum
dc.typeJournal Article
dcterms.source.volume5
dcterms.source.startPage330
dcterms.source.endPage335
dcterms.source.issn1573-3890
dcterms.source.titleMetabolomics
curtin.note

The original publication is available at: http://www.springerlink.com

curtin.departmentDepartment of Environment and Agriculture
curtin.accessStatusOpen access


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