An evaluation of CD39 as a novel immunoregulatory mechanism invoked by COPD
MetadataShow full item record
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are characterized by increased pulmonary and systemic inflammation and commonly caused by bacterial and/or viral infection. Little is known about the T-cell dysregulation in AECOPD that promotes these outcomes. CD39 is an ectonucleotidase able to hydrolyse adenosine triphosphate to create adenosine that may inhibit T-cell responses in patients with AECOPD. Here T-cell expression of CD39 measured by flow cytometry was higher in AECOPD patients than stable COPD patients or healthy controls. Higher expression of CD39 was associated with higher levels of plasma soluble tumor necrosis factor receptor but lower interferon-γ (IFNγ) levels in supernatants from staphylococcal enterotoxin-B stimulated peripheral blood mononuclear cells. This links increased expression of CD39 with systemic inflammation and impaired T-cell responses (e.g. IFNγ). The blockade of CD39 pathways may be a novel approach to the control of AECOPD, reducing the dependency on antibiotics.
Showing items related by title, author, creator and subject.
CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or ? d T-cells, in HIV patients responding to ARTTanaskovic, S.; Fernandez, S.; Price, Patricia; Lee, S.; French, M. (2010)Some severely immunodeficient HIV patients experience poor recovery of CD4 T-cell counts on antiretroviral therapy (ART). Evaluation of the function of thymopoiesis in T-cell production in individual patients requires a ...
Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency onantiretroviral therapy are associated with T-cell activation and senescenceTanaskovic, S.; Fernandez, S.; Price, Patricia; French, M. (2014)Objective: To examine the relationship of defects in interleukin (IL)-7-induced naive CD4+ T-cell homeostasis with residual immune activation and CD4+ T-cell senescence in HIV patients receiving antiretroviral therapy ...
Immunological profiles of immune restoration disease presenting as mycobacterial lymphadenitis and cryptococcal meningitisTan, D.; Yong, Y.; Tan, H.; Kamarulzaman, A.; Tan, L.; Lim, A.; James, I.; French, M.; Price, Patricia (2008)Objectives: A proportion of HIV patients beginning antiretroviral therapy (ART) develop immune restoration disease (IRD). Immunological characteristics of IRD were investigated in a cohort of HIV patients beginning therapy ...