In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy
MetadataShow full item record
Rationale: Xenobiotics in the maternal circulation are capable of crossing the placental barrier so a reduction in the mother and fetus's detoxification ability due to genetic variation in the glutathione S-transferases (GSTs) could expose the fetus to higher levels of toxins. Objectives: To investigate the interactive effects of maternal smoking during pregnancy with maternal and infant GST genotypes on airway responsiveness (AR) and lung function in infancy. Methods: GSTT1, GSTP1 and GSTM1 were genotyped in infants and mothers, in utero smoke exposure was evaluated by questionnaire, AR was assessed by histamine challenge and V?maxFRC was measured using the rapid thoracoabdominal compression technique. We investigated the interactive effects of maternal smoking during pregnancy with maternal and infant GST genes on AR and lung function at 1, 6, and 12 months and longitudinally throughout the first year. Measurements and Main Results: Infant and/or maternal GSTT1 nonnull was associated with reduced AR at 12 months and throughout the first year and increased V?maxFRC at 6 months. Maternal GSTP1 Val/Val or Ile/Val was associated with increased V?maxFRC at 6 months. In infants exposed to in utero smoke, infant and/or maternal GSTT1 nonnull was associated with reduced AR at 1 month and throughout the first year and increased V?maxFRC throughout the first year. Maternal GSTP1 Val/Val or Ile/Val was associated with increased V?maxFRC at 6 months. Conclusions: GST genes may be especially important during fetal development as they may modify, through proficient detoxification, the effects of in utero maternal smoke exposure on AR and lung function in infants.
Showing items related by title, author, creator and subject.
Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthoodOwens, L.; Laing, I.; Zhang, Guicheng; Turner, S.; Le Souëf, P. (2018)© 2018 Wiley Periodicals, Inc. Introduction: Increasing evidence suggests that poor lung function in adulthood is determined very early in life. Our study aims were: (1) identify factors associated with early infant lung ...
Modelling the co-occurence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tractJacoby, P.; Watson, K.; Bowman, J.; Taylor, A.; Riley, T.; Smith, D.; Lehmann, Deborah (2007)Go to ScienceDirect® Home Skip Main Navigation Links Brought to you by: The University of Western Australia Library Login: + Register Athens/Institution Login Not Registered? - User Name: Password: ...
Inoue, Madoka (2012)This thesis examines infant feeding practices, including knowledge and attitudes towards breastfeeding, factors that influence the duration of breastfeeding, and breastfeeding outcomes in relation to postpartum women’s ...