Show simple item record

dc.contributor.authorMurdzoska, J.
dc.contributor.authorDevadason, S.
dc.contributor.authorKhoo, S.
dc.contributor.authorLandau, L.
dc.contributor.authorYoung, S.
dc.contributor.authorGoldblatt, J.
dc.contributor.authorZhang, Guicheng
dc.contributor.authorLe Souëf, P.
dc.contributor.authorHayden, C.
dc.date.accessioned2017-01-30T12:42:01Z
dc.date.available2017-01-30T12:42:01Z
dc.date.created2016-09-12T08:36:29Z
dc.date.issued2010
dc.identifier.citationMurdzoska, J. and Devadason, S. and Khoo, S. and Landau, L. and Young, S. and Goldblatt, J. and Zhang, G. et al. 2010. In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy. American Journal of Respiratory and Critical Care Medicine. 181 (1): pp. 64-71.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/24274
dc.identifier.doi10.1164/rccm.200812-1887OC
dc.description.abstract

Rationale: Xenobiotics in the maternal circulation are capable of crossing the placental barrier so a reduction in the mother and fetus's detoxification ability due to genetic variation in the glutathione S-transferases (GSTs) could expose the fetus to higher levels of toxins. Objectives: To investigate the interactive effects of maternal smoking during pregnancy with maternal and infant GST genotypes on airway responsiveness (AR) and lung function in infancy. Methods: GSTT1, GSTP1 and GSTM1 were genotyped in infants and mothers, in utero smoke exposure was evaluated by questionnaire, AR was assessed by histamine challenge and V?maxFRC was measured using the rapid thoracoabdominal compression technique. We investigated the interactive effects of maternal smoking during pregnancy with maternal and infant GST genes on AR and lung function at 1, 6, and 12 months and longitudinally throughout the first year. Measurements and Main Results: Infant and/or maternal GSTT1 nonnull was associated with reduced AR at 12 months and throughout the first year and increased V?maxFRC at 6 months. Maternal GSTP1 Val/Val or Ile/Val was associated with increased V?maxFRC at 6 months. In infants exposed to in utero smoke, infant and/or maternal GSTT1 nonnull was associated with reduced AR at 1 month and throughout the first year and increased V?maxFRC throughout the first year. Maternal GSTP1 Val/Val or Ile/Val was associated with increased V?maxFRC at 6 months. Conclusions: GST genes may be especially important during fetal development as they may modify, through proficient detoxification, the effects of in utero maternal smoke exposure on AR and lung function in infants.

dc.publisherAmerican Thoracic Society
dc.titleIn utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy
dc.typeJournal Article
dcterms.source.volume181
dcterms.source.number1
dcterms.source.startPage64
dcterms.source.endPage71
dcterms.source.issn1073-449X
dcterms.source.titleAmerican Journal of Respiratory and Critical Care Medicine
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record