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The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults

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Authors
Lam, Virginie
Albrecht, Matthew
Takechi, Ryusuke
Giles, C.
James, Anthony
Foster, Jonathan
Mamo, John
Date
2013
Type
Journal Article

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Lam, Virginie and Albrecht, Matthew A. and Takechi, Ryusuke and Giles, Corey and James, Anthony P. and Foster, Jonathan K. and Mamo, John C. L. 2013. The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults. Frontiers in Aging Neuroscience. 5: Article 61.
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Frontiers in Aging Neuroscience
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Copyright: © 2013 Lam, Albrecht, Takechi, Giles, James, Foster and Mamo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Abstract

S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study investigated the relationship between serum S100B levels and neuropsychological performance across a range of cognitive domains in healthy older aged adults. A cohort of 219 participants between the ages of 43 and 84 years (141 female) were recruited. Subjects provided a fasting blood sample for S100B measurement (Mean = 0.24 ng/mL, SD = 0.14) and completed a battery of neuropsychological tests. S100B concentrations (both with and without the covariates of age and sex) were positively associated with the following measures of cognitive performance: digit-symbol coding, Stroop test, and measures of verbal ability. The results from this study show that serum S100B is positively associated with better cognitive performance in healthy older adults.