Show simple item record

dc.contributor.authorLam, Virginie
dc.contributor.authorAlbrecht, Matthew
dc.contributor.authorTakechi, Ryusuke
dc.contributor.authorGiles, C.
dc.contributor.authorJames, Anthony
dc.contributor.authorFoster, Jonathan
dc.contributor.authorMamo, John
dc.date.accessioned2017-01-30T12:45:58Z
dc.date.available2017-01-30T12:45:58Z
dc.date.created2013-10-30T20:00:35Z
dc.date.issued2013
dc.identifier.citationLam, Virginie and Albrecht, Matthew A. and Takechi, Ryusuke and Giles, Corey and James, Anthony P. and Foster, Jonathan K. and Mamo, John C. L. 2013. The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults. Frontiers in Aging Neuroscience. 5: Article 61.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/24957
dc.identifier.doi10.3389/fnagi.2013.00061
dc.description.abstract

S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study investigated the relationship between serum S100B levels and neuropsychological performance across a range of cognitive domains in healthy older aged adults. A cohort of 219 participants between the ages of 43 and 84 years (141 female) were recruited. Subjects provided a fasting blood sample for S100B measurement (Mean = 0.24 ng/mL, SD = 0.14) and completed a battery of neuropsychological tests. S100B concentrations (both with and without the covariates of age and sex) were positively associated with the following measures of cognitive performance: digit-symbol coding, Stroop test, and measures of verbal ability. The results from this study show that serum S100B is positively associated with better cognitive performance in healthy older adults.

dc.publisherFrontiers Research Foundation
dc.subjectAlzheimer’s disease
dc.subjectneuropsychological measures
dc.subjectS100B
dc.subjectBayesian analysis
dc.subjectneuro-inflammation
dc.titleThe Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults
dc.typeJournal Article
dcterms.source.volume5
dcterms.source.startPage1
dcterms.source.endPage6
dcterms.source.issn1663-4365
dcterms.source.titleFrontiers in Aging Neuroscience
curtin.note

Copyright: © 2013 Lam, Albrecht, Takechi, Giles, James, Foster and Mamo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

curtin.department
curtin.accessStatusOpen access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record