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    Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles

    Access Status
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    Authors
    Leite-Silva, V.
    Liu, D.
    Sanchez, W.
    Studier, H.
    Mohammed, Y.
    Holmes, A.
    Becker, W.
    Grice, J.
    Benson, Heather
    Roberts, M.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Leite-Silva, V. and Liu, D. and Sanchez, W. and Studier, H. and Mohammed, Y. and Holmes, A. and Becker, W. et al. 2016. Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles. Nanomedicine. 11 (10): pp. 1193-1205.
    Source Title
    Nanomedicine
    DOI
    10.2217/nnm-2016-0010
    ISSN
    1743-5889
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/25584
    Collection
    • Curtin Research Publications
    Abstract

    Aim: We assessed the effects of flexing and massage on human skin penetration and toxicity of topically applied coated and uncoated zinc oxide nanoparticles (75 nm) in vivo. Materials & methods: Noninvasive multiphoton tomography with fluorescence lifetime imaging was used to evaluate the penetration of nanoparticles through the skin barrier and cellular apoptosis in the viable epidermis. Results: All nanoparticles applied to skin with flexing and massage were retained in the stratum corneum or skin furrows. No significant penetration into the viable epidermis was seen and no cellular toxicity was detected. Conclusion: Exposure of normal in vivo human skin to these nanoparticles under common in-use conditions of flexing or massage is not associated with significant adverse events.

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