Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands
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2008Type
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Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor ß. © 2008 Elsevier Ltd. All rights reserved.
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Raval, S. and Raval, P. and Bandyopadhyay, D. and Soni, K. and Yevale, D. and Jogiya, D. and Modi, H. et al. 2008. Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands. Bioorganic & Medicinal Chemistry Letters. 18 (14): pp. 3919-3924.
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Bioorganic & Medicinal Chemistry Letters
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School of Biomedical Sciences
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