Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands

Raval, S.; Raval, P.; Bandyopadhyay, D.; Soni, K.; Yevale, D.; Jogiya, D.; Modi, H.; Joharapurkar, A.; Gandhi, Neha; Jain, M.; Patel, P.

doi:http://doi.org/10.1016/j.bmcl.2008.06.038

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Authors

Raval, S.

Raval, P.

Bandyopadhyay, D.

Soni, K.

Yevale, D.

Jogiya, D.

Modi, H.

Joharapurkar, A.

Gandhi, Neha

Jain, M.

Patel, P.

Date

2008

Type

Journal Article

Metadata

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Abstract

Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor ß. © 2008 Elsevier Ltd. All rights reserved.

Citation

Raval, S. and Raval, P. and Bandyopadhyay, D. and Soni, K. and Yevale, D. and Jogiya, D. and Modi, H. et al. 2008. Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands. Bioorganic & Medicinal Chemistry Letters. 18 (14): pp. 3919-3924.

Source Title

Bioorganic & Medicinal Chemistry Letters

URI

http://hdl.handle.net/20.500.11937/25636

DOI

http://doi.org/10.1016/j.bmcl.2008.06.038

Department

School of Biomedical Sciences

Collections

Research Papers