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    Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands

    Access Status
    Fulltext not available
    Authors
    Raval, S.
    Raval, P.
    Bandyopadhyay, D.
    Soni, K.
    Yevale, D.
    Jogiya, D.
    Modi, H.
    Joharapurkar, A.
    Gandhi, Neha
    Jain, M.
    Patel, P.
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Raval, S. and Raval, P. and Bandyopadhyay, D. and Soni, K. and Yevale, D. and Jogiya, D. and Modi, H. et al. 2008. Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands. Bioorganic & Medicinal Chemistry Letters. 18 (14): pp. 3919-3924.
    Source Title
    Bioorganic & Medicinal Chemistry Letters
    DOI
    10.1016/j.bmcl.2008.06.038
    ISSN
    0960-894X
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/25636
    Collection
    • Curtin Research Publications
    Abstract

    Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor ß. © 2008 Elsevier Ltd. All rights reserved.

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