Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands

Raval, S.; Raval, P.; Bandyopadhyay, D.; Soni, K.; Yevale, D.; Jogiya, D.; Modi, H.; Joharapurkar, A.; Gandhi, Neha; Jain, M.; Patel, P.

doi:10.1016/j.bmcl.2008.06.038

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Authors

Raval, S.

Raval, P.

Bandyopadhyay, D.

Soni, K.

Yevale, D.

Jogiya, D.

Modi, H.

Joharapurkar, A.

Gandhi, Neha

Jain, M.

Patel, P.

Date

2008

Type

Journal Article

Metadata

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Citation

Raval, S. and Raval, P. and Bandyopadhyay, D. and Soni, K. and Yevale, D. and Jogiya, D. and Modi, H. et al. 2008. Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands. Bioorganic & Medicinal Chemistry Letters. 18 (14): pp. 3919-3924.

Source Title

Bioorganic & Medicinal Chemistry Letters

DOI

10.1016/j.bmcl.2008.06.038

ISSN

0960-894X

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/25636

Collection

Curtin Research Publications

Abstract

Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor ß. © 2008 Elsevier Ltd. All rights reserved.