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    The association of host and genetic melanoma risk factors with Breslow thickness in the Western Australian Melanoma Health Study

    Access Status
    Open access via publisher
    Authors
    Cadby, G.
    Ward, S.
    Cole, J.
    Moses, Eric
    Millward, M.
    Palmer, L.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Cadby, G. and Ward, S. and Cole, J. and Moses, E. and Millward, M. and Palmer, L. 2014. The association of host and genetic melanoma risk factors with Breslow thickness in the Western Australian Melanoma Health Study. British Journal of Dermatology. 170 (4): pp. 851-857.
    Source Title
    British Journal of Dermatology
    DOI
    10.1111/bjd.12829
    ISSN
    0007-0963
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/26008
    Collection
    • Curtin Research Publications
    Abstract

    Background: Breslow thickness is the most important predictor of survival in localized malignant melanoma. A number of melanoma risk factors have been shown to be associated with Breslow thickness; however, the role of genetic loci has been little investigated to date. Objectives: To investigate the association of known melanoma susceptibility genetic loci with Breslow thickness. Methods: Participants were 800 individuals from the Western Australian Melanoma Health Study who completed a questionnaire and provided a DNA sample. Genetic association analyses between single-nucleotide polymorphisms (SNPs) from 15 candidate melanoma susceptibility genes and Breslow thickness were performed, controlling for relevant covariates. Results: Older age at diagnosis and absence of naevi were associated with increased Breslow thickness. Following adjustment for multiple testing, no SNPs were significantly associated with Breslow thickness. Conclusions: Associations observed between Breslow thickness and age and naevi reinforce current knowledge. Some evidence of shared genetic determinants between melanoma risk and Breslow thickness was found. Further studies are required to confirm this finding.

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