The effect on melanoma risk of genes previously associated with telomere length
Access Status
Open access via publisher
Authors
Iles, M.
Bishop, D.
Taylor, J.
Hayward, N.
Brossard, M.
Cust, A.
Dunning, A.
Lee, J.
Moses, Eric
Akslen, L.
Andresen, P.
Avril, M.
Azizi, E.
Scarra, G.
Brown, K.
Debniak, T.
Elder, D.
Friedman, E.
Ghiorzo, P.
Gillanders, E.
Goldstein, A.
Gruis, N.
Hansson, J.
Harland, M.
Helsing, P.
Hoçevar, M.
Hoiom, V.
Ingvar, C.
Kanetsky, P.
Landi, M.
Lang, J.
Lathrop, G.
Lubinski, J.
Mackie, R.
Martin, N.
Molven, A.
Montgomery, G.
Novakovi, S.
Olsson, H.
Puig, S.
Puig-Butille, J.
Radford-Smith, G.
Randerson-Moor, J.
Van Der Stoep, N.
Van Doorn, R.
Whiteman, D.
Macgregor, S.
Pooley, K.
Ward, S.
Mann, G.
Amos, C.
Pharoah, P.
Demenais, F.
Law, M.
Bishop, J.
Barrett, J.
Date
2014Type
Journal Article
Metadata
Show full item recordCitation
Iles, M. and Bishop, D. and Taylor, J. and Hayward, N. and Brossard, M. and Cust, A. and Dunning, A. et al. 2014. The effect on melanoma risk of genes previously associated with telomere length. Journal of the National Cancer Institute. 106 (10): dju267.
Source Title
Journal of the National Cancer Institute
ISSN
School
School of Biomedical Sciences
Collection
Abstract
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10-9, two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/3.0/
Related items
Showing items related by title, author, creator and subject.
-
Baragetti, A.; Palmen, J.; Garlaschelli, K.; Grigore, L.; Pellegatta, F.; Tragni, E.; Catapano, A.; Humphries, S.; Norata, Giuseppe; Talmud, P. (2015)© 2014 The Association for the Publication of the Journal of Internal Medicine. Introduction: Leucocyte telomere length (LTL) is an important determinant of telomere function and cellular replicative capacity. The aim of ...
-
Iles, M.; Bishop, D.; Taylor, J.; Hayward, N.; Brossard, M.; Cust, A.; Dunning, A.; Lee, J.; Moses, Eric; Akslen, L.; AMFS, I.; Andresen, P.; Avril, M.; Azizi, E.; Scarrà, G.; Brown, K.; Debniak, T.; Elder, D.; Friedman, E.; Ghiorzo, P.; Gillanders, E.; Goldstein, A.; Gruis, N.; Hansson, J.; Harland, M.; Helsing, P.; Hocevar, M.; Höiom, V.; IBD, I.; Ingvar, C.; Kanetsky, P.; Landi, M.; Lang, J.; Lathrop, G.; Lubinski, J.; Mackie, R.; Martin, N.; Molven, A.; Montgomery, G.; Novakovic, S.; Olsson, H.; Puig, S.; Puig-Butille, J.; QMEGA; Radford-Smith, G.; Randerson-Moor, J.; SDH, S.; van der Stoep, N.; van Doorn, R.; Whiteman, D.; MacGregor, S.; Pooley, K.; Ward, S.; Mann, G.; Amos, C.; Pharoah, P.; Demenais, F.; Law, M.; Newton Bishop, J.; Barrett, J.; GenoMEL, C. (2014)Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or ...
-
Codd, V.; Nelson, C.; Albrecht, E.; Mangino, M.; Deelen, J.; Buxton, J.; Hottenga, J.; Fischer, K.; Esko, T.; Surakka, I.; Broer, L.; Nyholt, D.; Leach, I.; Salo, P.; Hägg, S.; Matthews, M.; Palmen, J.; Norata, Giuseppe; O'Reilly, P.; Saleheen, D.; Amin, N.; Balmforth, A.; Beekman, M.; De Boer, R.; Böhringer, S.; Braund, P.; Burton, P.; Craen, A.; Denniff, M.; Dong, Y.; Douroudis, K.; Dubinina, E.; Eriksson, J.; Garlaschelli, K.; Guo, D.; Hartikainen, A.; Henders, A.; Houwing-Duistermaat, J.; Kananen, L.; Karssen, L.; Kettunen, J.; Klopp, N.; Lagou, V.; Van Leeuwen, E.; Madden, P.; Mägi, R.; Magnusson, P.; Männistö, S.; McCarthy, M.; Medland, S.; Mihailov, E.; Montgomery, G.; Oostra, B.; Palotie, A.; Peters, A.; Pollard, H.; Pouta, A.; Prokopenko, I.; Ripatti, S.; Salomaa, V.; Suchiman, H.; Valdes, A.; Verweij, N.; Viñuela, A.; Wang, X.; Wichmann, H.; Widen, E.; Willemsen, G.; Wright, M.; Xia, K.; Xiao, X.; Van Veldhuisen, D. (2013)Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with replication of selected ...