The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity

Wilkinson, S.; Gunosewoyo, Hendra; Barron, M.; Boucher, A.; McDonnell, M.; Turner, P.; Morrison, D.; Bennett, M.; McGregor, I.; Rendina, L.; Kassiou, M.

doi:10.1021/cn500054n

Access Status

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Authors

Wilkinson, S.

Gunosewoyo, Hendra

Barron, M.

Boucher, A.

McDonnell, M.

Turner, P.

Morrison, D.

Bennett, M.

McGregor, I.

Rendina, L.

Kassiou, M.

Date

2014

Type

Journal Article

Metadata

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Citation

Wilkinson, S. and Gunosewoyo, H. and Barron, M. and Boucher, A. and McDonnell, M. and Turner, P. and Morrison, D. et al. 2014. The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity. ACS Chemical Neuroscience. 5 (5): pp. 335-339.

Source Title

ACS Chemical Neuroscience

DOI

10.1021/cn500054n

ISSN

1948-7193

School

School of Pharmacy

URI

http://hdl.handle.net/20.500.11937/26070

Collection

Curtin Research Publications

Abstract

Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity